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- W3106760930 endingPage "129066" @default.
- W3106760930 startingPage "129066" @default.
- W3106760930 abstract "Fish consumption and chronic exposure to low doses of mercury (Hg) seems to activate several molecular mechanisms leading to carcinogenic and/or teratogenic processes. However, Hg genotoxic effects on humans are not completely described. In the present study, we assessed cytogenetic damage in isolated human peripheral lymphocytes using the cytokinesis-block micronucleus cytome assay (CBMN-Cyt), micronucleus formation with anti-kinetochore antibody (CREST staining), levels of total Hg in hair (T-Hg), fish consumption, and estimated Hg dose. The study comprised 39 non-exposed, and 73 residents from La Mojana region, an area with a well-documented Hg contamination. Data showed a significant increase in micronuclei (MNBN), nucleoplasmic bridges (NPB), and necrotic and apoptotic cell frequencies in residents of “La Mojana.” The overall mean T-Hg level in hair for exposed residents was 1.12 ± 0.94 mg kg−1 and 0.15 ± 0.05 in individuals from the reference area. Approximately 40% of analyzed individuals showed T-Hg levels that exceeded US Environmental Protection Agency (USEPA) reference dose. Increased T-Hg levels in hair were related to increased MNBN frequencies and high fish consumption. Other cellular markers, such as necrotic and apoptotic cell frequencies, were also correlated with high fish intake and T-Hg contents. Results of the CREST staining demonstrated that in vivo exposure to Hg induces genetic instability by chromosome fragment loss (clastogenic). Additionally, a high average intake of some fish species, particularly with carnivorous habits like Caquetaia kraussii, Hoplias malabaricus, and Sorubin cuspicaudus, seems to increase MNBN frequencies significantly." @default.
- W3106760930 created "2020-12-07" @default.
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- W3106760930 date "2021-02-01" @default.
- W3106760930 modified "2023-10-02" @default.
- W3106760930 title "Dietary exposure to mercury and its relation to cytogenetic instability in populations from “La Mojana” region, northern Colombia" @default.
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- W3106760930 doi "https://doi.org/10.1016/j.chemosphere.2020.129066" @default.
- W3106760930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33293049" @default.
- W3106760930 hasPublicationYear "2021" @default.
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