Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106768105> ?p ?o ?g. }
- W3106768105 endingPage "286" @default.
- W3106768105 startingPage "273" @default.
- W3106768105 abstract "Tumor cells need to cope with the host environment for survival and keep growing in hard conditions. This suggests that tumors must acquire characteristics more potent than what is seen for normal tissue cells, without which they are condemned to disruption. For example, cancer cells have more potent redox tolerance compared with normal cells, which is due to their high adaptation to an oxidative crisis. In addition, increased demand for bioenergetics and biosynthesis can cause a rise in nutrient uptake in tumors. Utilizing nutrients in low nutrient conditions suggests that tumors are also equipped with adaptive metabolic processes. Switching the metabolic demands toward glucose consumption upon exposure to the hypoxic tumor microenvironment, or changing toward using other sources when there is an overconsumption of glucose in the tumor area are examples of fitness metabolic systems in tumors. In fact, cancer cells in cooperation with their nearby stroma (in a process called metabolic coupling) can reprogram their metabolic systems in their favor. This suggests the high importance of stroma for meeting the metabolic demands of a growing tumor, an example in this context is the metabolic symbiosis between cancer-associated fibroblasts with cancer cells. The point is that redox tolerance and metabolic reprogramming are interrelated, and that, without a doubt, disruption of redox tolerance systems by transient exposure to either oxidative or antioxidative loading, or targeting metabolic rewiring by modulation of tumor glucose availability, controlling tumor/stroma interactions, etc. can be effective from a therapeutic standpoint." @default.
- W3106768105 created "2020-12-07" @default.
- W3106768105 creator A5090940628 @default.
- W3106768105 date "2020-12-08" @default.
- W3106768105 modified "2023-10-05" @default.
- W3106768105 title "Redox tolerance and metabolic reprogramming in solid tumors" @default.
- W3106768105 cites W1590981211 @default.
- W3106768105 cites W1745839265 @default.
- W3106768105 cites W1904885158 @default.
- W3106768105 cites W1969524738 @default.
- W3106768105 cites W1991926971 @default.
- W3106768105 cites W2007185373 @default.
- W3106768105 cites W2074673996 @default.
- W3106768105 cites W2075387097 @default.
- W3106768105 cites W2082046119 @default.
- W3106768105 cites W2106318552 @default.
- W3106768105 cites W2114090713 @default.
- W3106768105 cites W2123583425 @default.
- W3106768105 cites W2152943647 @default.
- W3106768105 cites W2159334325 @default.
- W3106768105 cites W2278001291 @default.
- W3106768105 cites W2304146082 @default.
- W3106768105 cites W2321750222 @default.
- W3106768105 cites W2345927750 @default.
- W3106768105 cites W2480105240 @default.
- W3106768105 cites W2534854440 @default.
- W3106768105 cites W2560786340 @default.
- W3106768105 cites W2568414132 @default.
- W3106768105 cites W2604883229 @default.
- W3106768105 cites W2620099834 @default.
- W3106768105 cites W2690859775 @default.
- W3106768105 cites W2735063286 @default.
- W3106768105 cites W2756466200 @default.
- W3106768105 cites W2760815906 @default.
- W3106768105 cites W2766580429 @default.
- W3106768105 cites W2767373540 @default.
- W3106768105 cites W2771485688 @default.
- W3106768105 cites W2773927148 @default.
- W3106768105 cites W2777639606 @default.
- W3106768105 cites W2790757017 @default.
- W3106768105 cites W2802992700 @default.
- W3106768105 cites W2804011812 @default.
- W3106768105 cites W2883704382 @default.
- W3106768105 cites W2885803994 @default.
- W3106768105 cites W2888631036 @default.
- W3106768105 cites W2890439734 @default.
- W3106768105 cites W2891417188 @default.
- W3106768105 cites W2893306535 @default.
- W3106768105 cites W2897498132 @default.
- W3106768105 cites W2902260254 @default.
- W3106768105 cites W2903362839 @default.
- W3106768105 cites W2905098668 @default.
- W3106768105 cites W2906490108 @default.
- W3106768105 cites W2914961857 @default.
- W3106768105 cites W2917418753 @default.
- W3106768105 cites W2918028648 @default.
- W3106768105 cites W2922133423 @default.
- W3106768105 cites W2923337193 @default.
- W3106768105 cites W2938629106 @default.
- W3106768105 cites W2943844582 @default.
- W3106768105 cites W2944703721 @default.
- W3106768105 cites W2945161487 @default.
- W3106768105 cites W2947110292 @default.
- W3106768105 cites W2952545916 @default.
- W3106768105 cites W2953979824 @default.
- W3106768105 cites W2954722149 @default.
- W3106768105 cites W2955641089 @default.
- W3106768105 cites W2961401903 @default.
- W3106768105 cites W2962287961 @default.
- W3106768105 cites W2970548174 @default.
- W3106768105 cites W2971532284 @default.
- W3106768105 cites W2971692433 @default.
- W3106768105 cites W2973769303 @default.
- W3106768105 cites W2975123998 @default.
- W3106768105 cites W2975852908 @default.
- W3106768105 cites W2979440788 @default.
- W3106768105 cites W2980329836 @default.
- W3106768105 cites W2980333794 @default.
- W3106768105 cites W2982135163 @default.
- W3106768105 cites W2982442619 @default.
- W3106768105 cites W2983010367 @default.
- W3106768105 cites W2983078243 @default.
- W3106768105 cites W2985637150 @default.
- W3106768105 cites W2985994020 @default.
- W3106768105 cites W2989776509 @default.
- W3106768105 cites W2993307622 @default.
- W3106768105 cites W2994080338 @default.
- W3106768105 cites W2998705129 @default.
- W3106768105 cites W2999853926 @default.
- W3106768105 cites W3000775170 @default.
- W3106768105 cites W3005827166 @default.
- W3106768105 cites W3009962865 @default.
- W3106768105 cites W3010327973 @default.
- W3106768105 cites W3011968719 @default.
- W3106768105 cites W3014445498 @default.
- W3106768105 cites W3023998523 @default.
- W3106768105 cites W3029079472 @default.
- W3106768105 cites W3035726534 @default.