FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106781990> ?p ?o ?g. }

• W3106781990 abstract "We report on the fabrication and characterisation of graphene field-effect transistor (GFET) biosensors for the detection of Clusterin, a prominent protein biomarker of Alzheimer’s disease (AD). The GFET sensors were fabricated on Si/SiO 2 substrate using photolithographic patterning and metal lift-off techniques with evaporated chromium and sputtered gold contacts. Raman Spectroscopy was performed on the devices to determine the quality of the graphene. The GFETs were annealed to improve their performance before the channels were functionalized by immobilising the graphene surface with linker molecules and anti-Clusterin antibodies. Concentration of linker molecules was also independently verified by absorption spectroscopy using the highly collimated micro-beam light of Diamond B23 beamline. The detection was achieved through the binding reaction between the antibody and varying concentrations of Clusterin antigen from 1 to 100 pg/mL, as well as specificity tests using human chorionic gonadotropin (hCG), a glycoprotein risk biomarker of certain cancers. The GFETs were characterized using direct current (DC) 4-probe electrical resistance (4-PER) measurements, which demonstrated a limit of detection of the biosensors to be ∼ 300 fg/mL (4 fM). Comparison with back-gated Dirac voltage shifts with varying concentration of Clusterin show 4-PER measurements to be more accurate, at present, and point to a requirement for further optimisation of the fabrication processes for our next generation of GFET sensors. Thus, we have successfully fabricated a promising set of GFET biosensors for the detection of Clusterin protein biomarker. The developed GFET biosensors are entirely generic and also have the potential to be applied to a variety of other disease detection applications such as Parkinson’s, cancer, and cardiovascular." @default.
• W3106781990 created "2020-12-07" @default.
• W3106781990 creator A5010301760 @default.
• W3106781990 creator A5030714244 @default.
• W3106781990 creator A5032712263 @default.
• W3106781990 creator A5034280332 @default.
• W3106781990 creator A5053099486 @default.
• W3106781990 creator A5063095380 @default.
• W3106781990 creator A5069095626 @default.
• W3106781990 creator A5090743190 @default.
• W3106781990 creator A5091142063 @default.
• W3106781990 date "2021-03-26" @default.
• W3106781990 modified "2023-10-16" @default.
• W3106781990 title "Graphene FET Sensors for Alzheimer’s Disease Protein Biomarker Clusterin Detection" @default.
• W3106781990 cites W1005658877 @default.
• W3106781990 cites W1484658605 @default.
• W3106781990 cites W1578820077 @default.
• W3106781990 cites W1755584404 @default.
• W3106781990 cites W1765586858 @default.
• W3106781990 cites W1821582401 @default.
• W3106781990 cites W1963687105 @default.
• W3106781990 cites W1986113254 @default.
• W3106781990 cites W1991859775 @default.
• W3106781990 cites W1992086000 @default.
• W3106781990 cites W1996649959 @default.
• W3106781990 cites W1998230670 @default.
• W3106781990 cites W1998440070 @default.
• W3106781990 cites W1999486225 @default.
• W3106781990 cites W1999594918 @default.
• W3106781990 cites W2002081866 @default.
• W3106781990 cites W2004102314 @default.
• W3106781990 cites W2013392245 @default.
• W3106781990 cites W2014694192 @default.
• W3106781990 cites W2018922793 @default.
• W3106781990 cites W2019460060 @default.
• W3106781990 cites W2022506474 @default.
• W3106781990 cites W2032920422 @default.
• W3106781990 cites W2035438942 @default.
• W3106781990 cites W2036288989 @default.
• W3106781990 cites W2042921414 @default.
• W3106781990 cites W2046758551 @default.
• W3106781990 cites W2046847750 @default.
• W3106781990 cites W2058122340 @default.
• W3106781990 cites W2059432259 @default.
• W3106781990 cites W2060009331 @default.
• W3106781990 cites W2061209448 @default.
• W3106781990 cites W2065514214 @default.
• W3106781990 cites W2072240475 @default.
• W3106781990 cites W2073675736 @default.
• W3106781990 cites W2074684620 @default.
• W3106781990 cites W2080880982 @default.
• W3106781990 cites W2094971181 @default.
• W3106781990 cites W2096410114 @default.
• W3106781990 cites W2101977779 @default.
• W3106781990 cites W2103413391 @default.
• W3106781990 cites W2105685140 @default.
• W3106781990 cites W2125284466 @default.
• W3106781990 cites W2132437915 @default.
• W3106781990 cites W2134090723 @default.
• W3106781990 cites W2134233006 @default.
• W3106781990 cites W2136334331 @default.
• W3106781990 cites W2138931463 @default.
• W3106781990 cites W2143646412 @default.
• W3106781990 cites W2146564548 @default.
• W3106781990 cites W2153711296 @default.
• W3106781990 cites W2154776931 @default.
• W3106781990 cites W2155455603 @default.
• W3106781990 cites W2156205508 @default.
• W3106781990 cites W2165469321 @default.
• W3106781990 cites W2329093977 @default.
• W3106781990 cites W2338141209 @default.
• W3106781990 cites W2606493132 @default.
• W3106781990 cites W2752701243 @default.
• W3106781990 cites W2783962031 @default.
• W3106781990 cites W2788473288 @default.
• W3106781990 cites W2958369617 @default.
• W3106781990 cites W2976050857 @default.
• W3106781990 cites W3014587231 @default.
• W3106781990 cites W3100247862 @default.
• W3106781990 cites W3102641627 @default.
• W3106781990 cites W3104914545 @default.
• W3106781990 cites W3129358670 @default.
• W3106781990 cites W3155196434 @default.
• W3106781990 cites W4244497140 @default.
• W3106781990 doi "https://doi.org/10.3389/fmolb.2021.651232" @default.
• W3106781990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8044944" @default.
• W3106781990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33869287" @default.
• W3106781990 hasPublicationYear "2021" @default.
• W3106781990 type Work @default.
• W3106781990 sameAs 3106781990 @default.
• W3106781990 citedByCount "16" @default.
• W3106781990 countsByYear W31067819902021 @default.
• W3106781990 countsByYear W31067819902022 @default.
• W3106781990 countsByYear W31067819902023 @default.
• W3106781990 crossrefType "journal-article" @default.
• W3106781990 hasAuthorship W3106781990A5010301760 @default.
• W3106781990 hasAuthorship W3106781990A5030714244 @default.
• W3106781990 hasAuthorship W3106781990A5032712263 @default.
• W3106781990 hasAuthorship W3106781990A5034280332 @default.
• W3106781990 hasAuthorship W3106781990A5053099486 @default.

• next