Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106813190> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3106813190 abstract "The morbidity of heart failure with preserved ejection fraction (HFpEF) increases with advanced age and is associated with endothelial dysfunction. In the present study, we analyzed the cardiac function and coronary microvascular function in endothelial specific SIRT3 knockout (ECKO) mice and global SIRT3 KO mice, as well as endothelial glycolytic metabolism and angiogenesis in vitro . We found that SIRT3 ECKO mice developed left ventricle (LV) diastolic dysfunction, as evidenced by prolonged isovolumic relaxation time (IVRT) and reduction of coronary flow reserve. Western blot analysis revealed a significant decrease in glycolytic enzyme PFKFB3 in SIRT3 KO-ECs, accompanied by a dramatic reduction in basal glycolysis, glycolytic reserve and glycolytic capacity. Moreover, SIRT3 KO-ECs exhibited higher oxygen consumption rate and more prominent production of reactive oxygen species (ROS) than WT-ECs. SIRT3 KO-ECs exhibited less potent angiogenic capabilities as indicated by decreased network formation and migration. In contrast, global knockout of SIRT3 in mice resulted in progressive deterioration of LV function, as evidenced by a decrease in ejection fraction and fraction shortening at 12 months of age. SIRT3 KO mice also exhibited reduction of ANP and ERK-1/2, and increased ROS production, gp91(phox), caspase-3 and Wnt7 in the heart. In conclusion, we demonstrated that ablation of SIRT3 in ECs caused an HFpEF phenotype with impaired glucose metabolism and angiogenesis. Global SIRT3 KO mice, however, exhibited an HFrEF phenotype. Our data suggest cell-specific effects of SIRT3 deletion on cardiac function." @default.
- W3106813190 created "2020-12-07" @default.
- W3106813190 creator A5015436281 @default.
- W3106813190 creator A5073545530 @default.
- W3106813190 creator A5075156483 @default.
- W3106813190 date "2017-09-01" @default.
- W3106813190 modified "2023-09-25" @default.
- W3106813190 title "Abstract P296: Deletion of Endothelial Sirt3 Causes Diastolic Dysfunction" @default.
- W3106813190 doi "https://doi.org/10.1161/hyp.70.suppl_1.p296" @default.
- W3106813190 hasPublicationYear "2017" @default.
- W3106813190 type Work @default.
- W3106813190 sameAs 3106813190 @default.
- W3106813190 citedByCount "0" @default.
- W3106813190 crossrefType "journal-article" @default.
- W3106813190 hasAuthorship W3106813190A5015436281 @default.
- W3106813190 hasAuthorship W3106813190A5073545530 @default.
- W3106813190 hasAuthorship W3106813190A5075156483 @default.
- W3106813190 hasConcept C111566952 @default.
- W3106813190 hasConcept C126322002 @default.
- W3106813190 hasConcept C134018914 @default.
- W3106813190 hasConcept C138488276 @default.
- W3106813190 hasConcept C181199279 @default.
- W3106813190 hasConcept C20251656 @default.
- W3106813190 hasConcept C2777099384 @default.
- W3106813190 hasConcept C2778198053 @default.
- W3106813190 hasConcept C2780394083 @default.
- W3106813190 hasConcept C2780561631 @default.
- W3106813190 hasConcept C2780972559 @default.
- W3106813190 hasConcept C48349386 @default.
- W3106813190 hasConcept C55493867 @default.
- W3106813190 hasConcept C62231903 @default.
- W3106813190 hasConcept C71924100 @default.
- W3106813190 hasConcept C75520062 @default.
- W3106813190 hasConcept C78085059 @default.
- W3106813190 hasConcept C86803240 @default.
- W3106813190 hasConceptScore W3106813190C111566952 @default.
- W3106813190 hasConceptScore W3106813190C126322002 @default.
- W3106813190 hasConceptScore W3106813190C134018914 @default.
- W3106813190 hasConceptScore W3106813190C138488276 @default.
- W3106813190 hasConceptScore W3106813190C181199279 @default.
- W3106813190 hasConceptScore W3106813190C20251656 @default.
- W3106813190 hasConceptScore W3106813190C2777099384 @default.
- W3106813190 hasConceptScore W3106813190C2778198053 @default.
- W3106813190 hasConceptScore W3106813190C2780394083 @default.
- W3106813190 hasConceptScore W3106813190C2780561631 @default.
- W3106813190 hasConceptScore W3106813190C2780972559 @default.
- W3106813190 hasConceptScore W3106813190C48349386 @default.
- W3106813190 hasConceptScore W3106813190C55493867 @default.
- W3106813190 hasConceptScore W3106813190C62231903 @default.
- W3106813190 hasConceptScore W3106813190C71924100 @default.
- W3106813190 hasConceptScore W3106813190C75520062 @default.
- W3106813190 hasConceptScore W3106813190C78085059 @default.
- W3106813190 hasConceptScore W3106813190C86803240 @default.
- W3106813190 hasIssue "suppl_1" @default.
- W3106813190 hasLocation W31068131901 @default.
- W3106813190 hasOpenAccess W3106813190 @default.
- W3106813190 hasPrimaryLocation W31068131901 @default.
- W3106813190 hasRelatedWork W1883738259 @default.
- W3106813190 hasRelatedWork W2028196543 @default.
- W3106813190 hasRelatedWork W2084171336 @default.
- W3106813190 hasRelatedWork W2332464694 @default.
- W3106813190 hasRelatedWork W2355756738 @default.
- W3106813190 hasRelatedWork W2965474825 @default.
- W3106813190 hasRelatedWork W2966588513 @default.
- W3106813190 hasRelatedWork W3039955948 @default.
- W3106813190 hasRelatedWork W4311462599 @default.
- W3106813190 hasRelatedWork W4376630782 @default.
- W3106813190 hasVolume "70" @default.
- W3106813190 isParatext "false" @default.
- W3106813190 isRetracted "false" @default.
- W3106813190 magId "3106813190" @default.
- W3106813190 workType "article" @default.