FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106832288> ?p ?o ?g. }

• W3106832288 endingPage "499" @default.
• W3106832288 startingPage "493" @default.
• W3106832288 abstract "ABSTRACT Introduction Botulinum toxin type A (BoNT/A) is an approved treatment for chronic migraine and has been shown to be effective in reducing number, days, and severity of headache in other headache disorders. Whether botulinum toxin is a safe and effective treatment specifically for post-traumatic headache (PTH), however, is unknown. This study sought to determine whether treatment with BoNT/A improved symptoms of PTH in military veterans. Materials and Methods Forty subjects with PTH were randomized to receive treatment of either BoNT/A or a saline placebo. Sixteen weeks post-treatment or at return to baseline headache severity, subjects were crossed over to receive treatment with the other medication than previously treated with in the first session. Subjects recorded number of headaches, number of headache days, and headache pain severity in daily diaries. Outcome measures included change in the weekly number of headaches, number of headache days per week, and headache pain severity compared to baseline, and the change in number of headaches and number of headaches days at baseline compared to the rating scores averaged across weeks 6–11. Results The number of headaches per week significantly decreased by 2.24 (43.3%) with BoNT/A treatment (P &lt; .001) and significantly increased by 1.28 (35.1%) with placebo (P = .02) at the end of the 16 weeks and the difference between groups was also significant (P &lt; .001). The number of headache days per week also significantly decreased by 2.24 (44.4%) at the end of 16 weeks with BoNT/A treatment (P &lt; .001), was not significantly changed with placebo, and the difference between the two groups was significant (P &lt; .001). Both the change in number of headaches and number of headache days averaged across weeks 6–11 compared to baseline were significantly decreased in the BoNT/A group (1.6 and 1.4, respectively) compared to a significant increase of 0.3 in number of weekly headaches and a nonsignificant decrease of 0.1 in number of headache days for the placebo group (P = .048 and P = .005, respectively). Headache pain severity was significantly reduced by 0.06 with botulinum toxin treatment (P = .02) and was not significantly increased by 0.04 in the placebo group with a significant difference between groups (P = .006). Conclusions Treatment with BoNT/A clinically and significantly improved the frequency and pain severity of PTH compared to placebo in military veterans. Limitations of the study include subject dropout, adherence to documenting variables daily in the dairy, and only one treatment of BoNT/A. Strengths include the cross-over study design, which demonstrated that BoNT/A was effective regardless of treatment order. This dataset is the first prospective study to evaluate BoNT/A as an intervention for symptoms of PTH and provides evidence that larger-scale and multiple treatment studies evaluating BoNT/A for this headache type are warranted." @default.
• W3106832288 created "2020-12-07" @default.
• W3106832288 creator A5004558032 @default.
• W3106832288 creator A5013583883 @default.
• W3106832288 creator A5037386890 @default.
• W3106832288 creator A5047616793 @default.
• W3106832288 creator A5051753473 @default.
• W3106832288 creator A5070990818 @default.
• W3106832288 creator A5082586741 @default.
• W3106832288 date "2021-05-01" @default.
• W3106832288 modified "2023-10-14" @default.
• W3106832288 title "Botulinum Toxin Type A for the Treatment of Post-traumatic Headache: A Randomized, Placebo-Controlled, Cross-over Study" @default.
• W3106832288 cites W1806864071 @default.
• W3106832288 cites W1973591002 @default.
• W3106832288 cites W2007410119 @default.
• W3106832288 cites W2019994261 @default.
• W3106832288 cites W204766049 @default.
• W3106832288 cites W2049857302 @default.
• W3106832288 cites W2056934567 @default.
• W3106832288 cites W2061592052 @default.
• W3106832288 cites W2064501211 @default.
• W3106832288 cites W2112260826 @default.
• W3106832288 cites W2128810790 @default.
• W3106832288 cites W2132968602 @default.
• W3106832288 cites W2137725714 @default.
• W3106832288 cites W2166281097 @default.
• W3106832288 cites W2167719770 @default.
• W3106832288 cites W2168098463 @default.
• W3106832288 cites W2172266844 @default.
• W3106832288 cites W2181841001 @default.
• W3106832288 cites W2288546638 @default.
• W3106832288 cites W2736848431 @default.
• W3106832288 cites W2796104859 @default.
• W3106832288 cites W2900420598 @default.
• W3106832288 cites W4230120862 @default.
• W3106832288 doi "https://doi.org/10.1093/milmed/usaa391" @default.
• W3106832288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33241323" @default.
• W3106832288 hasPublicationYear "2021" @default.
• W3106832288 type Work @default.
• W3106832288 sameAs 3106832288 @default.
• W3106832288 citedByCount "6" @default.
• W3106832288 countsByYear W31068322882021 @default.
• W3106832288 countsByYear W31068322882022 @default.
• W3106832288 countsByYear W31068322882023 @default.
• W3106832288 crossrefType "journal-article" @default.
• W3106832288 hasAuthorship W3106832288A5004558032 @default.
• W3106832288 hasAuthorship W3106832288A5013583883 @default.
• W3106832288 hasAuthorship W3106832288A5037386890 @default.
• W3106832288 hasAuthorship W3106832288A5047616793 @default.
• W3106832288 hasAuthorship W3106832288A5051753473 @default.
• W3106832288 hasAuthorship W3106832288A5070990818 @default.
• W3106832288 hasAuthorship W3106832288A5082586741 @default.
• W3106832288 hasBestOaLocation W31068322881 @default.
• W3106832288 hasConcept C126322002 @default.
• W3106832288 hasConcept C141071460 @default.
• W3106832288 hasConcept C142724271 @default.
• W3106832288 hasConcept C168563851 @default.
• W3106832288 hasConcept C1862650 @default.
• W3106832288 hasConcept C204787440 @default.
• W3106832288 hasConcept C27081682 @default.
• W3106832288 hasConcept C2777478456 @default.
• W3106832288 hasConcept C2778541695 @default.
• W3106832288 hasConcept C2780966972 @default.
• W3106832288 hasConcept C42219234 @default.
• W3106832288 hasConcept C71924100 @default.
• W3106832288 hasConceptScore W3106832288C126322002 @default.
• W3106832288 hasConceptScore W3106832288C141071460 @default.
• W3106832288 hasConceptScore W3106832288C142724271 @default.
• W3106832288 hasConceptScore W3106832288C168563851 @default.
• W3106832288 hasConceptScore W3106832288C1862650 @default.
• W3106832288 hasConceptScore W3106832288C204787440 @default.
• W3106832288 hasConceptScore W3106832288C27081682 @default.
• W3106832288 hasConceptScore W3106832288C2777478456 @default.
• W3106832288 hasConceptScore W3106832288C2778541695 @default.
• W3106832288 hasConceptScore W3106832288C2780966972 @default.
• W3106832288 hasConceptScore W3106832288C42219234 @default.
• W3106832288 hasConceptScore W3106832288C71924100 @default.
• W3106832288 hasFunder F4320314481 @default.
• W3106832288 hasIssue "5-6" @default.
• W3106832288 hasLocation W31068322881 @default.
• W3106832288 hasOpenAccess W3106832288 @default.
• W3106832288 hasPrimaryLocation W31068322881 @default.
• W3106832288 hasRelatedWork W2010448526 @default.
• W3106832288 hasRelatedWork W2026058186 @default.
• W3106832288 hasRelatedWork W2061251484 @default.
• W3106832288 hasRelatedWork W2064607382 @default.
• W3106832288 hasRelatedWork W2093724845 @default.
• W3106832288 hasRelatedWork W2164013489 @default.
• W3106832288 hasRelatedWork W253947354 @default.
• W3106832288 hasRelatedWork W2944260013 @default.
• W3106832288 hasRelatedWork W4221124466 @default.
• W3106832288 hasRelatedWork W4283359860 @default.
• W3106832288 hasVolume "186" @default.
• W3106832288 isParatext "false" @default.
• W3106832288 isRetracted "false" @default.
• W3106832288 magId "3106832288" @default.
• W3106832288 workType "article" @default.