FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106867711> ?p ?o ?g. }

• W3106867711 endingPage "23888" @default.
• W3106867711 startingPage "23872" @default.
• W3106867711 abstract "The current study was designed to seek the role of the glycogen synthase kinase-3β (GSK-β)-regulated NF-E2-related factor 2 (Nrf2) pathway in the antioxidant effect induced by Apigenin-7-O-β-D-(-6-p-coumaroyl)-glucopyranoside (APG). Rat primary cultured cortical neurons were challenged by oxygen and glucose deprivation/reoxygenation (OGD/R) and then treated with APG. Cell viability, phosphorylation of GSK-β at Ser9 and nuclear expression of Nrf2 were measured. Male Sprague Dawley rats challenged by 2-h middle cerebral artery occlusion were treated with 50 mg/kg APG, and the neurological score, infarct volume, phosphorylation of GSK-3β and nuclear expression of Nrf2 were analyzed. The neuroprotective effect of APG and the expression levels of antioxidant enzymes and oxidative products were also examined in the presence and absence of Nrf2-siRNA and PI3K inhibitors. APG reduced the apoptotic proportion, attenuated LDH release and increased cell viability, and in vivo, APG improved neurological scores and reduced infarct volume. APG increased GSK-3β phosphorylation and Nrf2 nuclear translocation, while these effects were prevented by PI3K inhibitors or Nrf2-siRNA treatment in both OGD/R cell cultures and ischemic/reperfusion rats. These findings reveal that GSK-3β phosphorylation-mediated Nrf2 activation is involved in the neuroprotective effect of APG." @default.
• W3106867711 created "2020-12-07" @default.
• W3106867711 creator A5003274991 @default.
• W3106867711 creator A5007078745 @default.
• W3106867711 creator A5007228314 @default.
• W3106867711 creator A5015514957 @default.
• W3106867711 creator A5020206515 @default.
• W3106867711 creator A5033098447 @default.
• W3106867711 creator A5035840666 @default.
• W3106867711 creator A5056342535 @default.
• W3106867711 creator A5059123552 @default.
• W3106867711 creator A5065988290 @default.
• W3106867711 creator A5088048815 @default.
• W3106867711 creator A5089896897 @default.
• W3106867711 creator A5090866405 @default.
• W3106867711 date "2020-11-18" @default.
• W3106867711 modified "2023-10-18" @default.
• W3106867711 title "Apigenin-7-<i>O</i>-<i>β</i>-D-(-6”-<i>p</i>-coumaroyl)-glucopyranoside treatment elicits a neuroprotective effect through GSK-3β phosphorylation-mediated Nrf2 activation" @default.
• W3106867711 cites W1166587220 @default.
• W3106867711 cites W1493831502 @default.
• W3106867711 cites W1624064684 @default.
• W3106867711 cites W1973821691 @default.
• W3106867711 cites W1974679183 @default.
• W3106867711 cites W1978094617 @default.
• W3106867711 cites W1981047775 @default.
• W3106867711 cites W2010740759 @default.
• W3106867711 cites W2013900800 @default.
• W3106867711 cites W2015843046 @default.
• W3106867711 cites W2026873752 @default.
• W3106867711 cites W2037288562 @default.
• W3106867711 cites W2039799157 @default.
• W3106867711 cites W2040114786 @default.
• W3106867711 cites W2077852011 @default.
• W3106867711 cites W2099231971 @default.
• W3106867711 cites W2112701033 @default.
• W3106867711 cites W2117318769 @default.
• W3106867711 cites W2118394016 @default.
• W3106867711 cites W2136280619 @default.
• W3106867711 cites W2146558971 @default.
• W3106867711 cites W2165500341 @default.
• W3106867711 cites W2171111385 @default.
• W3106867711 cites W2317798446 @default.
• W3106867711 cites W2336862132 @default.
• W3106867711 cites W2351673993 @default.
• W3106867711 cites W2408608526 @default.
• W3106867711 cites W2411734353 @default.
• W3106867711 cites W2430155480 @default.
• W3106867711 cites W2520566194 @default.
• W3106867711 cites W2525535049 @default.
• W3106867711 cites W2565324755 @default.
• W3106867711 cites W2593540775 @default.
• W3106867711 cites W2594903447 @default.
• W3106867711 cites W2597113820 @default.
• W3106867711 cites W2605157969 @default.
• W3106867711 cites W2610173397 @default.
• W3106867711 cites W2767982908 @default.
• W3106867711 cites W2790012847 @default.
• W3106867711 cites W2791828181 @default.
• W3106867711 cites W2799347886 @default.
• W3106867711 cites W2815578026 @default.
• W3106867711 cites W2889401286 @default.
• W3106867711 cites W2890433465 @default.
• W3106867711 cites W2910830636 @default.
• W3106867711 cites W2968458106 @default.
• W3106867711 cites W2972734535 @default.
• W3106867711 cites W2999531691 @default.
• W3106867711 cites W847785342 @default.
• W3106867711 doi "https://doi.org/10.18632/aging.104050" @default.
• W3106867711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7762462" @default.
• W3106867711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33263567" @default.
• W3106867711 hasPublicationYear "2020" @default.
• W3106867711 type Work @default.
• W3106867711 sameAs 3106867711 @default.
• W3106867711 citedByCount "11" @default.
• W3106867711 countsByYear W31068677112021 @default.
• W3106867711 countsByYear W31068677112022 @default.
• W3106867711 countsByYear W31068677112023 @default.
• W3106867711 crossrefType "journal-article" @default.
• W3106867711 hasAuthorship W3106867711A5003274991 @default.
• W3106867711 hasAuthorship W3106867711A5007078745 @default.
• W3106867711 hasAuthorship W3106867711A5007228314 @default.
• W3106867711 hasAuthorship W3106867711A5015514957 @default.
• W3106867711 hasAuthorship W3106867711A5020206515 @default.
• W3106867711 hasAuthorship W3106867711A5033098447 @default.
• W3106867711 hasAuthorship W3106867711A5035840666 @default.
• W3106867711 hasAuthorship W3106867711A5056342535 @default.
• W3106867711 hasAuthorship W3106867711A5059123552 @default.
• W3106867711 hasAuthorship W3106867711A5065988290 @default.
• W3106867711 hasAuthorship W3106867711A5088048815 @default.
• W3106867711 hasAuthorship W3106867711A5089896897 @default.
• W3106867711 hasAuthorship W3106867711A5090866405 @default.
• W3106867711 hasBestOaLocation W31068677111 @default.
• W3106867711 hasConcept C11960822 @default.
• W3106867711 hasConcept C185592680 @default.
• W3106867711 hasConcept C25498285 @default.
• W3106867711 hasConcept C2778004101 @default.
• W3106867711 hasConcept C2778609962 @default.
• W3106867711 hasConcept C2779054382 @default.

• next