Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106870469> ?p ?o ?g. }
- W3106870469 endingPage "4110" @default.
- W3106870469 startingPage "4098" @default.
- W3106870469 abstract "Selenoproteins are a family of special proteins that contain the 21st amino acid, selenocysteine (Sec), in their sequence. Selenoprotein P has 10 Sec residues and modulates selenium homeostasis and redox balance in the brain. Previously, we found that the Sec-devoid His-rich motif of selenoprotein P (Selenop-H) suppressed metal-induced aggregation and neurotoxicities of both Aβ and tau in vitro. To investigate the intervening capacity of Selenop-H on the neuropathology and cognitive deficits of triple transgenic AD (3 × Tg-AD) mice, the Selenop-H gene packaged in rAAV9 was delivered into the hippocampal CA3 regions of mice via stereotaxic injection. Four months later, we demonstrated that Selenop-H (1) improved the spatial learning and memory deficits, (2) alleviated neuron damage and synaptic protein loss, (3) inhibited both tau pathology and amyloid beta protein (Aβ) aggregation, (4) activated both BDNF- and Src-mediated TrkB signaling, and (5) increased MT3 and ZnT3 levels and restored Zn2+ homeostasis in the mice model of AD. The study revealed that Selenop-H is potent in ameliorating AD-related neuropathology and cognitive deficits by modulating TrkB signaling and Zn2+ homeostasis." @default.
- W3106870469 created "2020-12-07" @default.
- W3106870469 creator A5005908960 @default.
- W3106870469 creator A5006798023 @default.
- W3106870469 creator A5012301761 @default.
- W3106870469 creator A5018668445 @default.
- W3106870469 creator A5058968912 @default.
- W3106870469 creator A5084395008 @default.
- W3106870469 creator A5085307868 @default.
- W3106870469 creator A5087440046 @default.
- W3106870469 date "2020-11-23" @default.
- W3106870469 modified "2023-09-24" @default.
- W3106870469 title "His-Rich Domain of Selenoprotein P Ameliorates Neuropathology and Cognitive Deficits by Regulating TrkB Pathway and Zinc Homeostasis in an Alzheimer Model of Mice" @default.
- W3106870469 cites W1546288213 @default.
- W3106870469 cites W1599715713 @default.
- W3106870469 cites W1924557165 @default.
- W3106870469 cites W1971778269 @default.
- W3106870469 cites W1979881103 @default.
- W3106870469 cites W1987444426 @default.
- W3106870469 cites W1994580609 @default.
- W3106870469 cites W1996317447 @default.
- W3106870469 cites W2008980341 @default.
- W3106870469 cites W2032874774 @default.
- W3106870469 cites W2034578135 @default.
- W3106870469 cites W2037419631 @default.
- W3106870469 cites W2047731623 @default.
- W3106870469 cites W2049929625 @default.
- W3106870469 cites W2055667548 @default.
- W3106870469 cites W2058876934 @default.
- W3106870469 cites W2060893933 @default.
- W3106870469 cites W2063427689 @default.
- W3106870469 cites W2064038516 @default.
- W3106870469 cites W2065778432 @default.
- W3106870469 cites W2069780662 @default.
- W3106870469 cites W2081287258 @default.
- W3106870469 cites W2082794570 @default.
- W3106870469 cites W2082871116 @default.
- W3106870469 cites W2083500052 @default.
- W3106870469 cites W2089972903 @default.
- W3106870469 cites W2094544368 @default.
- W3106870469 cites W2094958540 @default.
- W3106870469 cites W2096166220 @default.
- W3106870469 cites W2097459689 @default.
- W3106870469 cites W2102999439 @default.
- W3106870469 cites W2121753059 @default.
- W3106870469 cites W2122946015 @default.
- W3106870469 cites W2129418389 @default.
- W3106870469 cites W2131181742 @default.
- W3106870469 cites W2157069791 @default.
- W3106870469 cites W2157659941 @default.
- W3106870469 cites W2161771658 @default.
- W3106870469 cites W2163639252 @default.
- W3106870469 cites W2165978935 @default.
- W3106870469 cites W2169063473 @default.
- W3106870469 cites W2187526329 @default.
- W3106870469 cites W2293608890 @default.
- W3106870469 cites W2322766024 @default.
- W3106870469 cites W2329661376 @default.
- W3106870469 cites W2578865974 @default.
- W3106870469 cites W2581457142 @default.
- W3106870469 cites W2594072479 @default.
- W3106870469 cites W2612114080 @default.
- W3106870469 cites W2766411457 @default.
- W3106870469 cites W2776184041 @default.
- W3106870469 cites W2911743376 @default.
- W3106870469 cites W2921147283 @default.
- W3106870469 cites W2953901603 @default.
- W3106870469 cites W3216995939 @default.
- W3106870469 cites W4243538184 @default.
- W3106870469 doi "https://doi.org/10.1021/acschemneuro.0c00278" @default.
- W3106870469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33226214" @default.
- W3106870469 hasPublicationYear "2020" @default.
- W3106870469 type Work @default.
- W3106870469 sameAs 3106870469 @default.
- W3106870469 citedByCount "9" @default.
- W3106870469 countsByYear W31068704692021 @default.
- W3106870469 countsByYear W31068704692022 @default.
- W3106870469 countsByYear W31068704692023 @default.
- W3106870469 crossrefType "journal-article" @default.
- W3106870469 hasAuthorship W3106870469A5005908960 @default.
- W3106870469 hasAuthorship W3106870469A5006798023 @default.
- W3106870469 hasAuthorship W3106870469A5012301761 @default.
- W3106870469 hasAuthorship W3106870469A5018668445 @default.
- W3106870469 hasAuthorship W3106870469A5058968912 @default.
- W3106870469 hasAuthorship W3106870469A5084395008 @default.
- W3106870469 hasAuthorship W3106870469A5085307868 @default.
- W3106870469 hasAuthorship W3106870469A5087440046 @default.
- W3106870469 hasConcept C102230213 @default.
- W3106870469 hasConcept C104317684 @default.
- W3106870469 hasConcept C126322002 @default.
- W3106870469 hasConcept C141035611 @default.
- W3106870469 hasConcept C148762608 @default.
- W3106870469 hasConcept C160539049 @default.
- W3106870469 hasConcept C169760540 @default.
- W3106870469 hasConcept C170493617 @default.
- W3106870469 hasConcept C178790620 @default.
- W3106870469 hasConcept C185592680 @default.
- W3106870469 hasConcept C2776151105 @default.