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- W3106870740 abstract "Regulatory T cells (Tregs) regulate immune responses and maintain host immune homeostasis. Tregs contribute to the disease progression of several chronic infections by oversuppressing immune responses via the secretion of immunosuppressive cytokines, such as transforming growth factor (TGF)-β and interleukin-10. In the present study, we examined the association of Tregs with Mycoplasma bovis infection, in which immunosuppression is frequently observed. Compared with uninfected cattle, the percentage of Tregs, CD4 + CD25 high Foxp3 + T cells, was increased in M . bovis -infected cattle. Additionally, the plasma of M . bovis -infected cattle contained the high concentrations of TGF-β1, and M . bovis infection induced TGF-β1 production from bovine immune cells in in vitro cultures. Finally, we analyzed the immunosuppressive effects of TGF-β1 on bovine immune cells. Treatment with TGF-β1 significantly decreased the expression of CD69, an activation marker, in T cells, and Th1 cytokine production in vitro . These results suggest that the increase in Tregs and TGF-β1 secretion could be one of the immunosuppressive mechanisms and that lead to increased susceptibility to other infections in terms of exacerbation of disease during M . bovis infection." @default.
- W3106870740 created "2020-12-07" @default.
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- W3106870740 date "2020-12-02" @default.
- W3106870740 modified "2023-10-01" @default.
- W3106870740 title "The Suppression of Th1 Response by Inducing TGF-β1 From Regulatory T Cells in Bovine Mycoplasmosis" @default.
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- W3106870740 doi "https://doi.org/10.3389/fvets.2020.609443" @default.
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