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- W3106873756 abstract "Mean platelet volume (MPV) is a marker of inflammation that indicates the average size of platelets, platelet production rate and stimulation. The role of Pre-operative levels of MPV and its prognostic effect on disease free survival (DFS) and overall survival (OS) are poorly understood. This study was intended to analyze the effect of pre-operative levels of MPV on DFS and OS of stage III rectal cancer patients. This is a retrospective study of 149 stage III rectal cancer patients who underwent surgery in our institution between 2011 and 2015. Association between pre-operative levels of MPV and clinicopathological variables were analysed. DFS and OS for 5 years were analysed, and survival analysis was done using Kaplan-Meier curve. MPV of 9.35 femto litres (fl) was chosen based on the ROC curve. The Area under curve was 0.889. Differences between survival curves were analysed for statistical significance using log-rank test. In our study, mean 5-year OS were 91.1 and 50.36 months, for patients with MPV < 9.35 and MPV >9.35 respectively (P 0.0001). The mean DFS of MPV < 9.35 and MPV > 9.35 were 89.32 and 43.54 months respectively (P 0.0001). Univariate analysis for OS and DFS showed significance for MPV, Nodal status, Circumferential resection margin, stage and lymph node ratio. Multivariate analysis showed significance for MPV [HR 2.379 (95% CI 1.733-3.264) P .0001 for MPV>9.35] and CRM [HR 0.392 (95% CI 0.191-0.804) P 0.01) for CRM negative] for OS and DFS. Multivariate Analysis for OS & DFSTable: 94PVariableOSDFSP valueHazard Ratio95% CIP valueHazard Ratio95% CILowerUpperLowerUpperN StageN1a.782.785.1404.390.824.833.1674.146N1b.119.322.0771.340.159.389.1041.448N2a.554.715.2352.175.680.810.2972.209N2bReferenceReferenceCRMNegative.011.392.191.804.012.412.207.821PositiveReferenceReferenceStageIIIA.568.692.1962.447.203.465.1431.510IIIB.474.727.3031.743.203.607.2811.310IIICReferenceReferenceMPV>9.35.00012.3791.7333.264.00012.3701.7913.136<9.35ReferenceReferenceLNR ratio>0.2.2203.269.49221.738.0595.756.93835.327<0.2ReferenceReference Open table in a new tab . Pre-operative MPV measured one week before surgery is a convenient and inexpensive marker which has been proved to be a prognostic marker for OS and DFS in stage III rectal cancer patients." @default.
- W3106873756 created "2020-12-07" @default.
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- W3106873756 date "2020-11-01" @default.
- W3106873756 modified "2023-09-30" @default.
- W3106873756 title "94P Prognostic influence of mean platelet volume on stage III rectal cancer patients: A tertiary cancer center study" @default.
- W3106873756 doi "https://doi.org/10.1016/j.annonc.2020.10.114" @default.
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