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• W3106874121 abstract "Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hundreds of adaptive yeast mutants responds to subtle environmental shifts. We then model the number of phenotypes these mutations collectively influence by decomposing these patterns of fitness variation. We find that a small number of inferred phenotypes can predict fitness of the adaptive mutations near their original glucose-limited evolution condition. Importantly, inferred phenotypes that matter little to fitness at or near the evolution condition can matter strongly in distant environments. This suggests that adaptive mutations are locally modular — affecting a small number of phenotypes that matter to fitness in the environment where they evolved — yet globally pleiotropic — affecting additional phenotypes that may reduce or improve fitness in new environments." @default.
• W3106874121 created "2020-12-07" @default.
• W3106874121 creator A5073659297 @default.
• W3106874121 creator A5079773342 @default.
• W3106874121 creator A5082597456 @default.
• W3106874121 date "2020-12-02" @default.
• W3106874121 modified "2023-10-02" @default.
• W3106874121 title "Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation" @default.
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