Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106887006> ?p ?o ?g. }
- W3106887006 endingPage "14" @default.
- W3106887006 startingPage "1" @default.
- W3106887006 abstract "Mitochondria are major sources of reactive oxygen species (ROS) within the cell and are especially vulnerable to oxidative stress. Oxidative damage to mitochondria results in disrupted mitochondrial function and cell death signaling, finally triggering diverse pathologies such as epilepsy, a common neurological disease characterized with aberrant electrical brain activity. Antioxidants are considered as promising neuroprotective strategies for epileptic condition via combating the deleterious effects of excessive ROS production in mitochondria. In this review, we provide a brief discussion of the role of mitochondrial oxidative stress in the pathophysiology of epilepsy and evidences that support neuroprotective roles of antioxidants targeting mitochondrial oxidative stress including mitochondria-targeted antioxidants, polyphenols, vitamins, thiols, and nuclear factor E2-related factor 2 (Nrf2) activators in epilepsy. We point out these antioxidative compounds as effectively protective approaches for improving prognosis. In addition, we specially propose that these antioxidants exert neuroprotection against epileptic impairment possibly by modulating cell death interactions, notably autophagy-apoptosis, and autophagy-ferroptosis crosstalk." @default.
- W3106887006 created "2020-12-07" @default.
- W3106887006 creator A5003621404 @default.
- W3106887006 creator A5005160394 @default.
- W3106887006 creator A5026593700 @default.
- W3106887006 creator A5031961975 @default.
- W3106887006 creator A5039136187 @default.
- W3106887006 creator A5057346122 @default.
- W3106887006 creator A5075452426 @default.
- W3106887006 date "2020-11-25" @default.
- W3106887006 modified "2023-10-14" @default.
- W3106887006 title "Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy" @default.
- W3106887006 cites W1540615713 @default.
- W3106887006 cites W1970554352 @default.
- W3106887006 cites W1973256301 @default.
- W3106887006 cites W1974564805 @default.
- W3106887006 cites W1980510037 @default.
- W3106887006 cites W1985538633 @default.
- W3106887006 cites W1985717888 @default.
- W3106887006 cites W1986078216 @default.
- W3106887006 cites W1989310221 @default.
- W3106887006 cites W2005574929 @default.
- W3106887006 cites W2005904867 @default.
- W3106887006 cites W2008757142 @default.
- W3106887006 cites W2011989008 @default.
- W3106887006 cites W2017733129 @default.
- W3106887006 cites W2018563185 @default.
- W3106887006 cites W2034087770 @default.
- W3106887006 cites W2034132165 @default.
- W3106887006 cites W2041471383 @default.
- W3106887006 cites W2042141597 @default.
- W3106887006 cites W2049126461 @default.
- W3106887006 cites W2050422609 @default.
- W3106887006 cites W2055815530 @default.
- W3106887006 cites W2055976032 @default.
- W3106887006 cites W2056351424 @default.
- W3106887006 cites W2078184099 @default.
- W3106887006 cites W2085850488 @default.
- W3106887006 cites W2106878843 @default.
- W3106887006 cites W2111715221 @default.
- W3106887006 cites W2124105006 @default.
- W3106887006 cites W2134877431 @default.
- W3106887006 cites W2135089655 @default.
- W3106887006 cites W2140254470 @default.
- W3106887006 cites W2149938392 @default.
- W3106887006 cites W2152165298 @default.
- W3106887006 cites W2154919554 @default.
- W3106887006 cites W2157250831 @default.
- W3106887006 cites W2163632151 @default.
- W3106887006 cites W2183013629 @default.
- W3106887006 cites W2185200386 @default.
- W3106887006 cites W2267153940 @default.
- W3106887006 cites W2339153852 @default.
- W3106887006 cites W2407681580 @default.
- W3106887006 cites W2486467989 @default.
- W3106887006 cites W2500857469 @default.
- W3106887006 cites W2516050404 @default.
- W3106887006 cites W2605924432 @default.
- W3106887006 cites W2612692728 @default.
- W3106887006 cites W2620099834 @default.
- W3106887006 cites W2621389072 @default.
- W3106887006 cites W2625947545 @default.
- W3106887006 cites W2728715382 @default.
- W3106887006 cites W2763777263 @default.
- W3106887006 cites W2779556084 @default.
- W3106887006 cites W2788048790 @default.
- W3106887006 cites W2789752518 @default.
- W3106887006 cites W2791315418 @default.
- W3106887006 cites W2791934000 @default.
- W3106887006 cites W2792077782 @default.
- W3106887006 cites W2793066160 @default.
- W3106887006 cites W2793273629 @default.
- W3106887006 cites W2803132862 @default.
- W3106887006 cites W2806391280 @default.
- W3106887006 cites W2885025259 @default.
- W3106887006 cites W2892944171 @default.
- W3106887006 cites W2898195830 @default.
- W3106887006 cites W2902895647 @default.
- W3106887006 cites W2904259759 @default.
- W3106887006 cites W2911824951 @default.
- W3106887006 cites W2916533298 @default.
- W3106887006 cites W2921138669 @default.
- W3106887006 cites W2923362583 @default.
- W3106887006 cites W2941016603 @default.
- W3106887006 cites W2946078377 @default.
- W3106887006 cites W2946568609 @default.
- W3106887006 cites W2946801360 @default.
- W3106887006 cites W2948588876 @default.
- W3106887006 cites W2951163658 @default.
- W3106887006 cites W2951832587 @default.
- W3106887006 cites W2956475702 @default.
- W3106887006 cites W2964257868 @default.
- W3106887006 cites W2965242736 @default.
- W3106887006 cites W2965848535 @default.
- W3106887006 cites W2970172987 @default.
- W3106887006 cites W2970588504 @default.
- W3106887006 cites W2971494264 @default.
- W3106887006 cites W2971532316 @default.