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- W3106890367 abstract "Abstract The Transforming Growth Factor-β (TGFβ) signaling pathway controls transcription by regulating enhancer activity. How TGFβ-regulated enhancers are selected and what chromatin changes are associated with TGFβ-dependent enhancers regulation are still unclear. Here we report that TGFβ treatment triggers fast and widespread increase in chromatin accessibility in about 80% of the enhancers of normal mouse mammary epithelial-gland cells, irrespective of whether they are activated, repressed or not regulated by TGFβ. This enhancer opening depends on both the canonical and non-canonical TGFβ pathways. Most TGFβ-regulated genes are located around enhancers regulated in the same way, often creating domains of several co-regulated genes that we term TGFβ regulatory domains (TRD). CRISPR-mediated inactivation of enhancers within TRDs impairs TGFβ-dependent regulation of all co-regulated genes, demonstrating that enhancer targeting is more promiscuous than previously anticipated. The area of TRD influence is restricted by topologically associating domains (TADs) borders, causing a bias towards co-regulation within TADs." @default.
- W3106890367 created "2020-12-07" @default.
- W3106890367 creator A5011921181 @default.
- W3106890367 creator A5015737356 @default.
- W3106890367 creator A5046087406 @default.
- W3106890367 creator A5050473824 @default.
- W3106890367 creator A5089921732 @default.
- W3106890367 date "2020-12-03" @default.
- W3106890367 modified "2023-10-14" @default.
- W3106890367 title "TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains" @default.
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