FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106942997> ?p ?o ?g. }

• W3106942997 endingPage "28" @default.
• W3106942997 startingPage "28" @default.
• W3106942997 abstract "Background: The Balaruc-les-Bains’ thermal mud was found to be colonized predominantly by microorganisms, with cyanobacteria constituting the primary organism in the microbial biofilm observed on the mud surface. The success of cyanobacteria in colonizing this specific ecological niche can be explained in part by their taxa-specific adaptation capacities, and also the diversity of bioactive natural products that they synthesize. This array of components has physiological and ecological properties that may be exploited for various applications. Methods: Nine cyanobacterial strains were isolated from Balaruc thermal mud and maintained in the Paris Museum Collection (PMC). Full genome sequencing was performed coupled with targeted and untargeted metabolomic analyses (HPLC-DAD and LC-MS/MS). Bioassays were performed to determine antioxidant, anti-inflammatory, and wound-healing properties. Results: Biosynthetic pathways for phycobiliproteins, scytonemin, and carotenoid pigments and 124 metabolite biosynthetic gene clusters (BGCs) were characterized. Several compounds with known antioxidant or anti-inflammatory properties, such as carotenoids, phycobilins, mycosporine-like amino acids, and aeruginosins, and other bioactive metabolites like microginins, microviridins, and anabaenolysins were identified. Secretion of the proinflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 appeared to be inhibited by crude extracts of Planktothricoides raciborskii PMC 877.14, Nostoc sp. PMC 881.14, and Pseudo-chroococcus couteii PMC 885.14. The extract of the Aliinostoc sp. PMC 882.14 strain was able to slightly enhance migration of HaCat cells that may be helpful in wound healing. Several antioxidant compounds were detected, but no significant effects on nitric oxide secretion were observed. There was no cytotoxicity on the three cell types tested, indicating that cyanobacterial extracts may have anti-inflammatory therapeutic potential without harming body cells. These data open up promising uses for these extracts and their respective molecules in drugs or thermal therapies." @default.
• W3106942997 created "2020-12-07" @default.
• W3106942997 creator A5003039679 @default.
• W3106942997 creator A5006939791 @default.
• W3106942997 creator A5025683789 @default.
• W3106942997 creator A5040027522 @default.
• W3106942997 creator A5046575152 @default.
• W3106942997 creator A5054862903 @default.
• W3106942997 creator A5063590249 @default.
• W3106942997 creator A5072172103 @default.
• W3106942997 creator A5073430690 @default.
• W3106942997 creator A5088004044 @default.
• W3106942997 creator A5089674900 @default.
• W3106942997 date "2020-12-29" @default.
• W3106942997 modified "2023-10-18" @default.
• W3106942997 title "Anti-Inflammatory, Antioxidant, and Wound-Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-Les-Bains, France: A Multi-Approach Study" @default.
• W3106942997 cites W1492002819 @default.
• W3106942997 cites W1854118849 @default.
• W3106942997 cites W1880092145 @default.
• W3106942997 cites W1967265143 @default.
• W3106942997 cites W1969209088 @default.
• W3106942997 cites W1971193341 @default.
• W3106942997 cites W1971842724 @default.
• W3106942997 cites W1974450649 @default.
• W3106942997 cites W1991138711 @default.
• W3106942997 cites W2000770184 @default.
• W3106942997 cites W2008968942 @default.
• W3106942997 cites W2009744584 @default.
• W3106942997 cites W2014695652 @default.
• W3106942997 cites W2015171291 @default.
• W3106942997 cites W2016981590 @default.
• W3106942997 cites W2020390356 @default.
• W3106942997 cites W2033898136 @default.
• W3106942997 cites W2040529970 @default.
• W3106942997 cites W2040898201 @default.
• W3106942997 cites W2047559410 @default.
• W3106942997 cites W2051698064 @default.
• W3106942997 cites W2055982675 @default.
• W3106942997 cites W2056664979 @default.
• W3106942997 cites W2058011207 @default.
• W3106942997 cites W2063220206 @default.
• W3106942997 cites W2068653760 @default.
• W3106942997 cites W2073054137 @default.
• W3106942997 cites W2075555781 @default.
• W3106942997 cites W2077207999 @default.
• W3106942997 cites W2084318917 @default.
• W3106942997 cites W2088845669 @default.
• W3106942997 cites W2101002869 @default.
• W3106942997 cites W2112364185 @default.
• W3106942997 cites W2120902911 @default.
• W3106942997 cites W2121023856 @default.
• W3106942997 cites W2154083822 @default.
• W3106942997 cites W2169474553 @default.
• W3106942997 cites W2179359515 @default.
• W3106942997 cites W2208709848 @default.
• W3106942997 cites W2340027296 @default.
• W3106942997 cites W2343244702 @default.
• W3106942997 cites W2362284325 @default.
• W3106942997 cites W2397739328 @default.
• W3106942997 cites W2406187369 @default.
• W3106942997 cites W2406842056 @default.
• W3106942997 cites W2410975458 @default.
• W3106942997 cites W2510483127 @default.
• W3106942997 cites W2512542445 @default.
• W3106942997 cites W2578123690 @default.
• W3106942997 cites W2593127685 @default.
• W3106942997 cites W2609567109 @default.
• W3106942997 cites W2613519842 @default.
• W3106942997 cites W2620085140 @default.
• W3106942997 cites W2735527928 @default.
• W3106942997 cites W2765178242 @default.
• W3106942997 cites W2767721154 @default.
• W3106942997 cites W2769281525 @default.
• W3106942997 cites W2775781666 @default.
• W3106942997 cites W2809637358 @default.
• W3106942997 cites W2897178933 @default.
• W3106942997 cites W2902210669 @default.
• W3106942997 cites W2911308605 @default.
• W3106942997 cites W2937096712 @default.
• W3106942997 cites W2937164721 @default.
• W3106942997 cites W2942829220 @default.
• W3106942997 cites W2950354111 @default.
• W3106942997 cites W2951816104 @default.
• W3106942997 cites W2952167528 @default.
• W3106942997 cites W2980832688 @default.
• W3106942997 cites W2981413553 @default.
• W3106942997 cites W2981519702 @default.
• W3106942997 cites W2994786999 @default.
• W3106942997 cites W3000469349 @default.
• W3106942997 cites W3001959067 @default.
• W3106942997 cites W3015647039 @default.
• W3106942997 cites W3017288814 @default.
• W3106942997 cites W3033340892 @default.
• W3106942997 cites W3112771775 @default.
• W3106942997 cites W393204881 @default.
• W3106942997 doi "https://doi.org/10.3390/biom11010028" @default.
• W3106942997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7824682" @default.
• W3106942997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33383796" @default.

• next