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- W3106961467 endingPage "262" @default.
- W3106961467 startingPage "251" @default.
- W3106961467 abstract "Intratumour heterogeneity and phenotypic plasticity, sustained by a range of somatic aberrations, as well as epigenetic and metabolic adaptations, are the principal mechanisms that enable cancers to resist treatment and survive under environmental stress. A comprehensive picture of the interplay between different somatic aberrations, from point mutations to whole-genome duplications, in tumour initiation and progression is lacking. We posit that different genomic aberrations generally exhibit a temporal order, shaped by a balance between the levels of mutations and selective pressures. Repeat instability emerges first, followed by larger aberrations, with compensatory effects leading to robust tumour fitness maintained throughout the tumour progression. A better understanding of the interplay between genetic aberrations, the microenvironment, and epigenetic and metabolic cellular states is essential for early detection and prevention of cancer as well as development of efficient therapeutic strategies." @default.
- W3106961467 created "2020-12-07" @default.
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- W3106961467 date "2020-11-30" @default.
- W3106961467 modified "2023-10-16" @default.
- W3106961467 title "Mutation–selection balance and compensatory mechanisms in tumour evolution" @default.
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