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• W3106968574 abstract "SRY-box transcription factor 2 (SOX2) overlapping transcript (SOX2-OT) is an evolutionarily conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major regulator of the pluripotency of embryonic stem cells. The human SOX2-OT gene comprises multiple exons and has multiple transcription start sites and generates hundreds of transcripts. Transcription factors (IRF4, AR, and SOX3), transcriptional inhibitors (NSPc1, MTA3, and YY1), and miRNAs (miR-211 and miR-375) have been demonstrated to control certain SOX2-OT transcript level at the transcriptional or posttranscriptional levels. Accumulated evidence indicates its crucial roles in the regulation of the SOX2 gene, miRNAs, and transcriptional process. Restricted expression of SOX2-OT transcripts in the brain results in the association between SOX2-OT single nucleotide polymorphisms and mental illnesses such as schizophrenia and anorexia nervosa. SOX2-OT is notably elevated in tumor tissues, and a high level of SOX2-OT is well correlated with poor clinical outcomes in cancer patients, leading to the establishment of its role as an oncogene and a prognostic or diagnostic biomarker for cancers. The emerging evidence supports that SOX2-OT mediates diabetic complications. In summary, SOX2-OT has diversified functions and could be a therapeutic target for various diseases." @default.
• W3106968574 created "2020-12-07" @default.
• W3106968574 creator A5045370323 @default.
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• W3106968574 date "2020-11-26" @default.
• W3106968574 modified "2023-10-10" @default.
• W3106968574 title "Long Noncoding RNA SOX2-OT: Regulations, Functions, and Roles on Mental Illnesses, Cancers, and Diabetic Complications" @default.
• W3106968574 cites W1560986311 @default.
• W3106968574 cites W1571632853 @default.
• W3106968574 cites W1585687822 @default.
• W3106968574 cites W1973260880 @default.
• W3106968574 cites W1982846895 @default.
• W3106968574 cites W1989057528 @default.
• W3106968574 cites W2004382890 @default.
• W3106968574 cites W2010203835 @default.
• W3106968574 cites W2036921369 @default.
• W3106968574 cites W2108356100 @default.
• W3106968574 cites W2111832790 @default.
• W3106968574 cites W2114996028 @default.
• W3106968574 cites W2157981274 @default.
• W3106968574 cites W2162547088 @default.
• W3106968574 cites W2163141464 @default.
• W3106968574 cites W2166070816 @default.
• W3106968574 cites W2184997675 @default.
• W3106968574 cites W2205277042 @default.
• W3106968574 cites W2278506812 @default.
• W3106968574 cites W2302541819 @default.
• W3106968574 cites W2344375774 @default.
• W3106968574 cites W2344450687 @default.
• W3106968574 cites W2401811918 @default.
• W3106968574 cites W2404312699 @default.
• W3106968574 cites W2560654380 @default.
• W3106968574 cites W2565218155 @default.
• W3106968574 cites W2566908060 @default.
• W3106968574 cites W2588280606 @default.
• W3106968574 cites W2612236189 @default.
• W3106968574 cites W2735505419 @default.
• W3106968574 cites W2753400121 @default.
• W3106968574 cites W2758160127 @default.
• W3106968574 cites W2760519858 @default.
• W3106968574 cites W2763836527 @default.
• W3106968574 cites W2765241643 @default.
• W3106968574 cites W2767955698 @default.
• W3106968574 cites W2771310992 @default.
• W3106968574 cites W2775148687 @default.
• W3106968574 cites W2777667999 @default.
• W3106968574 cites W2782460431 @default.
• W3106968574 cites W2791397134 @default.
• W3106968574 cites W2796759472 @default.
• W3106968574 cites W2799727067 @default.
• W3106968574 cites W2803224814 @default.
• W3106968574 cites W2804564195 @default.
• W3106968574 cites W2804610669 @default.
• W3106968574 cites W2804899894 @default.
• W3106968574 cites W2806309723 @default.
• W3106968574 cites W2806395345 @default.
• W3106968574 cites W2883573930 @default.
• W3106968574 cites W2884148611 @default.
• W3106968574 cites W2887929353 @default.
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• W3106968574 cites W2891127333 @default.
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• W3106968574 cites W2894772994 @default.
• W3106968574 cites W2895599024 @default.
• W3106968574 cites W2896510555 @default.
• W3106968574 cites W2898654660 @default.
• W3106968574 cites W2905138054 @default.
• W3106968574 cites W2909486692 @default.
• W3106968574 cites W2909598358 @default.
• W3106968574 cites W2912671852 @default.
• W3106968574 cites W2914355932 @default.
• W3106968574 cites W2915402738 @default.
• W3106968574 cites W2917156127 @default.
• W3106968574 cites W2920679757 @default.
• W3106968574 cites W2937022288 @default.
• W3106968574 cites W2938436598 @default.
• W3106968574 cites W2944433097 @default.
• W3106968574 cites W2945634900 @default.
• W3106968574 cites W2952686929 @default.
• W3106968574 cites W2959639261 @default.
• W3106968574 cites W2980260756 @default.
• W3106968574 cites W2980509570 @default.
• W3106968574 cites W2983765585 @default.
• W3106968574 cites W2984145949 @default.
• W3106968574 cites W2987121543 @default.
• W3106968574 cites W2994631251 @default.
• W3106968574 cites W2997830067 @default.
• W3106968574 cites W3001936777 @default.
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• W3106968574 doi "https://doi.org/10.1155/2020/2901589" @default.
• W3106968574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7718063" @default.
• W3106968574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33294436" @default.

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