FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3106975975> ?p ?o ?g. }

• W3106975975 endingPage "105318" @default.
• W3106975975 startingPage "105318" @default.
• W3106975975 abstract "The role of high mobility group box 1 (HMGB1) has been recognized as important, and suppression of HMGB1 release and restoration of vascular barrier integrity are regarded as potentially promising therapeutic strategies against sepsis. Hederacolchiside-E (HCE), namely 3-O-{α-L-rhamnopyranosyl (1→2)-[β-D-glucopyranosyl(1→4)]-α-L-arabinopyranosyl}-28-O-[α-L-rhamnopyranosyl (1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl ester, is a bidesmosidic oleanane saponin first isolated in 1970 from the leaves of Hedera colchica. We tested our hypothesis that HCE inhibits HMGB1-induced vascular hyperpermeability and thereby increases the survival of septic mouse model from suppression of HMGB1 release upon lipopolysaccharide (LPS)-stimulation. In LPS-activated human endothelial cells and a sepsis mouse model by cecal ligation and puncture (CLP), antiseptic activity of HCE was investigated from suppression of vascular permeability, pro-inflammatory proteins, and tissue injury markers. Post-treatment of HCE significantly suppressed HMGB1 release both in LPS-activated human endothelial cells and the CLP-induced sepsis mouse model. HCE inhibited hyperpermeability and alleviated HMGB1-mediated vascular disruptions, and reduced sepsis-related mortality and tissue injury in mice. Our results suggest that reduction of HMGB1 release and septic mortality by HCE may be useful for the drug candidate of sepsis, indicating a possibility of successful repositioning of HCE." @default.
• W3106975975 created "2020-12-07" @default.
• W3106975975 creator A5020927837 @default.
• W3106975975 creator A5038674172 @default.
• W3106975975 creator A5042655034 @default.
• W3106975975 creator A5054602576 @default.
• W3106975975 creator A5057134188 @default.
• W3106975975 creator A5080543997 @default.
• W3106975975 date "2021-01-01" @default.
• W3106975975 modified "2023-10-17" @default.
• W3106975975 title "Barrier protective functions of hederacolchiside-E against HMGB1-mediated septic responses" @default.
• W3106975975 cites W1934726430 @default.
• W3106975975 cites W1965923704 @default.
• W3106975975 cites W1972230443 @default.
• W3106975975 cites W1978558320 @default.
• W3106975975 cites W1985638455 @default.
• W3106975975 cites W2016169910 @default.
• W3106975975 cites W2026184625 @default.
• W3106975975 cites W2026744070 @default.
• W3106975975 cites W2029001868 @default.
• W3106975975 cites W2029068688 @default.
• W3106975975 cites W2031558790 @default.
• W3106975975 cites W2051924508 @default.
• W3106975975 cites W2056121092 @default.
• W3106975975 cites W2057602456 @default.
• W3106975975 cites W2061214188 @default.
• W3106975975 cites W2076243684 @default.
• W3106975975 cites W2095609344 @default.
• W3106975975 cites W2097236514 @default.
• W3106975975 cites W2100155786 @default.
• W3106975975 cites W2101907617 @default.
• W3106975975 cites W2136973716 @default.
• W3106975975 cites W2146807706 @default.
• W3106975975 cites W2160369507 @default.
• W3106975975 cites W2164714222 @default.
• W3106975975 cites W2171783221 @default.
• W3106975975 cites W2172953381 @default.
• W3106975975 cites W2532705306 @default.
• W3106975975 cites W2623246154 @default.
• W3106975975 cites W2745962715 @default.
• W3106975975 cites W2770359401 @default.
• W3106975975 cites W2781157943 @default.
• W3106975975 cites W2784696743 @default.
• W3106975975 cites W2793843202 @default.
• W3106975975 cites W2889377140 @default.
• W3106975975 cites W2902407026 @default.
• W3106975975 cites W2909130796 @default.
• W3106975975 cites W2943731257 @default.
• W3106975975 cites W2951652562 @default.
• W3106975975 cites W3009097075 @default.
• W3106975975 cites W3009630426 @default.
• W3106975975 cites W4238585520 @default.
• W3106975975 cites W748993927 @default.
• W3106975975 doi "https://doi.org/10.1016/j.phrs.2020.105318" @default.
• W3106975975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33246171" @default.
• W3106975975 hasPublicationYear "2021" @default.
• W3106975975 type Work @default.
• W3106975975 sameAs 3106975975 @default.
• W3106975975 citedByCount "5" @default.
• W3106975975 countsByYear W31069759752022 @default.
• W3106975975 countsByYear W31069759752023 @default.
• W3106975975 crossrefType "journal-article" @default.
• W3106975975 hasAuthorship W3106975975A5020927837 @default.
• W3106975975 hasAuthorship W3106975975A5038674172 @default.
• W3106975975 hasAuthorship W3106975975A5042655034 @default.
• W3106975975 hasAuthorship W3106975975A5054602576 @default.
• W3106975975 hasAuthorship W3106975975A5057134188 @default.
• W3106975975 hasAuthorship W3106975975A5080543997 @default.
• W3106975975 hasConcept C113045295 @default.
• W3106975975 hasConcept C126322002 @default.
• W3106975975 hasConcept C142724271 @default.
• W3106975975 hasConcept C185592680 @default.
• W3106975975 hasConcept C203014093 @default.
• W3106975975 hasConcept C2776914184 @default.
• W3106975975 hasConcept C2778384902 @default.
• W3106975975 hasConcept C2778754761 @default.
• W3106975975 hasConcept C2780545709 @default.
• W3106975975 hasConcept C2781460226 @default.
• W3106975975 hasConcept C71924100 @default.
• W3106975975 hasConcept C98274493 @default.
• W3106975975 hasConceptScore W3106975975C113045295 @default.
• W3106975975 hasConceptScore W3106975975C126322002 @default.
• W3106975975 hasConceptScore W3106975975C142724271 @default.
• W3106975975 hasConceptScore W3106975975C185592680 @default.
• W3106975975 hasConceptScore W3106975975C203014093 @default.
• W3106975975 hasConceptScore W3106975975C2776914184 @default.
• W3106975975 hasConceptScore W3106975975C2778384902 @default.
• W3106975975 hasConceptScore W3106975975C2778754761 @default.
• W3106975975 hasConceptScore W3106975975C2780545709 @default.
• W3106975975 hasConceptScore W3106975975C2781460226 @default.
• W3106975975 hasConceptScore W3106975975C71924100 @default.
• W3106975975 hasConceptScore W3106975975C98274493 @default.
• W3106975975 hasFunder F4320322120 @default.
• W3106975975 hasLocation W31069759751 @default.
• W3106975975 hasOpenAccess W3106975975 @default.
• W3106975975 hasPrimaryLocation W31069759751 @default.
• W3106975975 hasRelatedWork W1489786451 @default.
• W3106975975 hasRelatedWork W1533966244 @default.

• next