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- W3106990631 abstract "Bisphenol A (BPA) is an endocrine disruptor that negatively affects spermatogenesis, a process where Sertoli cells play a central role. Thus, in the present study we sought to ascertain whether BPA could modulate the endocannabinoid (eCB) system in exposed mouse primary Sertoli cells. Under our experimental conditions, BPA turned out to be cytotoxic to Sertoli cells with an half-maximal inhibitory concentration (IC50) of ~6.0 µM. Exposure to a non-cytotoxic dose of BPA (i.e., 0.5 μM for 48 h) increased the expression levels of specific components of the eCB system, namely: type-1 cannabinoid (CB1) receptor and diacylglycerol lipase-α (DAGL-α), at mRNA level, type-2 cannabinoid (CB2) receptor, transient receptor potential vanilloid 1 (TRPV1) receptors, and DAGL-β, at protein level. Interestingly, BPA also increased the production of inhibin B, but not that of transferrin, and blockade of either CB2 receptor or TRPV1 receptor further enhanced the BPA effect. Altogether, our study provides unprecedented evidence that BPA deranges the eCB system of Sertoli cells towards CB2- and TRPV1-dependent signal transduction, both receptors being engaged in modulating BPA effects on inhibin B production. These findings add CB2 and TRPV1 receptors, and hence the eCB signaling, to the other molecular targets of BPA already known in mammalian cells." @default.
- W3106990631 created "2020-12-07" @default.
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- W3106990631 date "2020-11-26" @default.
- W3106990631 modified "2023-09-26" @default.
- W3106990631 title "Bisphenol A Deranges the Endocannabinoid System of Primary Sertoli Cells with an Impact on Inhibin B Production" @default.
- W3106990631 cites W1492021038 @default.
- W3106990631 cites W1494951837 @default.
- W3106990631 cites W1550225938 @default.
- W3106990631 cites W1624980904 @default.
- W3106990631 cites W1971883646 @default.
- W3106990631 cites W1978879076 @default.
- W3106990631 cites W1979938143 @default.
- W3106990631 cites W1994413221 @default.
- W3106990631 cites W2000781649 @default.
- W3106990631 cites W2002535987 @default.
- W3106990631 cites W2009770671 @default.
- W3106990631 cites W2013557239 @default.
- W3106990631 cites W2022466555 @default.
- W3106990631 cites W2023704290 @default.
- W3106990631 cites W2026387596 @default.
- W3106990631 cites W2027511147 @default.
- W3106990631 cites W2031972537 @default.
- W3106990631 cites W2040879761 @default.
- W3106990631 cites W2042371501 @default.
- W3106990631 cites W2042515261 @default.
- W3106990631 cites W2043319761 @default.
- W3106990631 cites W2046326345 @default.
- W3106990631 cites W2048582924 @default.
- W3106990631 cites W2049970571 @default.
- W3106990631 cites W2053029537 @default.
- W3106990631 cites W2057798856 @default.
- W3106990631 cites W2062734801 @default.
- W3106990631 cites W2067314116 @default.
- W3106990631 cites W2067753015 @default.
- W3106990631 cites W2068809017 @default.
- W3106990631 cites W2076231699 @default.
- W3106990631 cites W2078532788 @default.
- W3106990631 cites W2078764376 @default.
- W3106990631 cites W2081746977 @default.
- W3106990631 cites W2088144381 @default.
- W3106990631 cites W2090759332 @default.
- W3106990631 cites W2093315658 @default.
- W3106990631 cites W2100247356 @default.
- W3106990631 cites W2102079086 @default.
- W3106990631 cites W2102188803 @default.
- W3106990631 cites W2109004804 @default.
- W3106990631 cites W2112755850 @default.
- W3106990631 cites W2114729638 @default.
- W3106990631 cites W2114918609 @default.
- W3106990631 cites W2119352549 @default.
- W3106990631 cites W2127449847 @default.
- W3106990631 cites W2129786180 @default.
- W3106990631 cites W2134450626 @default.
- W3106990631 cites W2136306240 @default.
- W3106990631 cites W2140834096 @default.
- W3106990631 cites W2157770461 @default.
- W3106990631 cites W2162830803 @default.
- W3106990631 cites W2165342671 @default.
- W3106990631 cites W2166806732 @default.
- W3106990631 cites W2200441591 @default.
- W3106990631 cites W2275300427 @default.
- W3106990631 cites W2294566933 @default.
- W3106990631 cites W2335530136 @default.
- W3106990631 cites W2399811012 @default.
- W3106990631 cites W2409344007 @default.
- W3106990631 cites W2417596961 @default.
- W3106990631 cites W2507186624 @default.
- W3106990631 cites W2522794999 @default.
- W3106990631 cites W2539237186 @default.
- W3106990631 cites W2616178001 @default.
- W3106990631 cites W2736041600 @default.
- W3106990631 cites W2749135113 @default.
- W3106990631 cites W2763314163 @default.
- W3106990631 cites W2789353908 @default.
- W3106990631 cites W2794998024 @default.
- W3106990631 cites W2804424348 @default.
- W3106990631 cites W2906038772 @default.
- W3106990631 cites W2923625930 @default.
- W3106990631 cites W2937600593 @default.
- W3106990631 cites W2939451090 @default.
- W3106990631 cites W2944215734 @default.
- W3106990631 cites W2950467275 @default.
- W3106990631 cites W2956388707 @default.
- W3106990631 cites W2973469872 @default.
- W3106990631 cites W2992838111 @default.
- W3106990631 cites W2995855682 @default.
- W3106990631 cites W2996366748 @default.