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- W3107007061 abstract "The long-term efficacy of targeted therapeutics for cancer treatment can be significantly limited by the type of therapy and development of drug resistance, inter alia. Experimental studies indicate that the factors enhancing acquisition of drug resistance in cancer cells include cell heterogeneity, drug target alteration, drug inactivation, DNA damage repair, drug efflux, cell death inhibition, as well as microenvironmental adaptations to targeted therapy, among others. Combination cancer therapies (CCTs) are employed to overcome these molecular and pathophysiological bottlenecks and improve the overall survival of cancer patients. CCTs often utilize multiple combinatorial modes of action and thus potentially constitute a promising approach to overcome drug resistance. Considering the colossal cost, human effort, time and ethical issues involved in clinical drug trials and basic medical research, mathematical modeling and analysis can potentially contribute immensely to the discovery of better cancer treatment regimens. In this article, we review mathematical models on CCTs developed thus far for cancer management. Open questions are highlighted and plausible combinations are discussed based on the level of toxicity, drug resistance, survival benefits, preclinical trials and other side effects." @default.
- W3107007061 created "2020-12-07" @default.
- W3107007061 creator A5014519945 @default.
- W3107007061 creator A5065064582 @default.
- W3107007061 creator A5074618036 @default.
- W3107007061 creator A5083053202 @default.
- W3107007061 date "2020-11-12" @default.
- W3107007061 modified "2023-09-27" @default.
- W3107007061 title "The future of cancer treatments: a critical review of mathematical models for combination cancer therapy" @default.
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