Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107044138> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W3107044138 endingPage "928" @default.
- W3107044138 startingPage "927.4" @default.
- W3107044138 abstract "TransposonsTransposable element activity has been associated with cancer genomes, but whether this activity drives cancers or is incidental to tumorigenesis has been difficult to resolve. Tiwari et al. tested the function of the oncogene p53 on LINE1s, transposable elements found in human cells. Oncogene p53 stimulates repressive histone marks on LINE1s, which keeps them from replicating. If p53 becomes mutated in human cells, the epigenetic repressors on the LINE1s are not maintained. This allows LINE1s to become hyperactivate and replicate within the genome. In some cases, this causes chromosomal breakage, a hallmark of p53 loss-of-function cancers, and stimulates inflammation. Thus, when function is lost in p53 mutants and LINE1 activity increases, an acute oncogenic crisis looms.Genes Dev. 34 , 1439 (2020)." @default.
- W3107044138 created "2020-12-07" @default.
- W3107044138 creator A5001149521 @default.
- W3107044138 date "2020-11-19" @default.
- W3107044138 modified "2023-09-25" @default.
- W3107044138 title "Transposable drivers or passengers?" @default.
- W3107044138 doi "https://doi.org/10.1126/science.370.6519.927-d" @default.
- W3107044138 hasPublicationYear "2020" @default.
- W3107044138 type Work @default.
- W3107044138 sameAs 3107044138 @default.
- W3107044138 citedByCount "0" @default.
- W3107044138 crossrefType "journal-article" @default.
- W3107044138 hasAuthorship W3107044138A5001149521 @default.
- W3107044138 hasBestOaLocation W31070441381 @default.
- W3107044138 hasConcept C104317684 @default.
- W3107044138 hasConcept C105951970 @default.
- W3107044138 hasConcept C121608353 @default.
- W3107044138 hasConcept C127716648 @default.
- W3107044138 hasConcept C14036430 @default.
- W3107044138 hasConcept C141231307 @default.
- W3107044138 hasConcept C197077220 @default.
- W3107044138 hasConcept C2781018059 @default.
- W3107044138 hasConcept C29537977 @default.
- W3107044138 hasConcept C41091548 @default.
- W3107044138 hasConcept C4918238 @default.
- W3107044138 hasConcept C54355233 @default.
- W3107044138 hasConcept C555283112 @default.
- W3107044138 hasConcept C64927066 @default.
- W3107044138 hasConcept C86803240 @default.
- W3107044138 hasConceptScore W3107044138C104317684 @default.
- W3107044138 hasConceptScore W3107044138C105951970 @default.
- W3107044138 hasConceptScore W3107044138C121608353 @default.
- W3107044138 hasConceptScore W3107044138C127716648 @default.
- W3107044138 hasConceptScore W3107044138C14036430 @default.
- W3107044138 hasConceptScore W3107044138C141231307 @default.
- W3107044138 hasConceptScore W3107044138C197077220 @default.
- W3107044138 hasConceptScore W3107044138C2781018059 @default.
- W3107044138 hasConceptScore W3107044138C29537977 @default.
- W3107044138 hasConceptScore W3107044138C41091548 @default.
- W3107044138 hasConceptScore W3107044138C4918238 @default.
- W3107044138 hasConceptScore W3107044138C54355233 @default.
- W3107044138 hasConceptScore W3107044138C555283112 @default.
- W3107044138 hasConceptScore W3107044138C64927066 @default.
- W3107044138 hasConceptScore W3107044138C86803240 @default.
- W3107044138 hasIssue "6519" @default.
- W3107044138 hasLocation W31070441381 @default.
- W3107044138 hasOpenAccess W3107044138 @default.
- W3107044138 hasPrimaryLocation W31070441381 @default.
- W3107044138 hasRelatedWork W12565879 @default.
- W3107044138 hasRelatedWork W16961552 @default.
- W3107044138 hasRelatedWork W20595148 @default.
- W3107044138 hasRelatedWork W25389013 @default.
- W3107044138 hasRelatedWork W26899763 @default.
- W3107044138 hasRelatedWork W28301123 @default.
- W3107044138 hasRelatedWork W30212099 @default.
- W3107044138 hasRelatedWork W55809 @default.
- W3107044138 hasRelatedWork W8423158 @default.
- W3107044138 hasRelatedWork W9103934 @default.
- W3107044138 hasVolume "370" @default.
- W3107044138 isParatext "false" @default.
- W3107044138 isRetracted "false" @default.
- W3107044138 magId "3107044138" @default.
- W3107044138 workType "article" @default.