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• W3107059233 abstract "Abstract Targeted, stimulus‐responsive DNA nanogels hold considerable promise for cancer therapeutics. To expand their functionality including thermoresponsiveness, here, multifunctional DNA nanogels are developed for potential application toward cancer‐targeted delivery and stimuli‐responsive release of cancer therapeutics. Three types of functionalized DNA nanobuilding units are formed into DNA nanogels of ≈200 nm via sequence‐dependent self‐assembly. The sequence‐dependent assembly of nanobuilding units is precisely designed for controlled assembly and thermal disassembly at physiological temperatures. The supramolecular structure exhibits multifunctionalities including temperature‐induced disassembly, aptamer‐mediated cancer cell targeting, and light‐triggered temperature increase. The nanogels support co‐loading of cancer therapeutics including anti‐sense oligonucleotides and doxorubicin along with stimuli‐responsive release of loaded drugs through temperature‐responsive structural disassembly and pH‐responsive deintercalation. The nanogels exhibit efficient aptamer‐mediated cancer‐specific intracellular delivery and combinational anticancer effects upon light triggering. The developed DNA nanogels, thus, constitute potential noncationic nanovectors for targeted delivery of combinational cancer therapeutics." @default.
• W3107059233 created "2020-12-07" @default.
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• W3107059233 date "2020-11-23" @default.
• W3107059233 modified "2023-10-02" @default.
• W3107059233 title "Multifunctional DNA Nanogels for Aptamer‐Based Targeted Delivery and Stimuli‐Triggered Release of Cancer Therapeutics" @default.
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• W3107059233 doi "https://doi.org/10.1002/marc.202000457" @default.
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