Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107156932> ?p ?o ?g. }
- W3107156932 endingPage "5655" @default.
- W3107156932 startingPage "5655" @default.
- W3107156932 abstract "Biofilm production is regulated by the Quorum Sensing system. Nowadays, Quorum Sensing represents an appealing target to design new compounds to increase antibiotics effects and avoid development of antibiotics multiresistance. In this research the use of liposomes to target two novel synthetic biofilm inhibitors is presented, focusing on a preformulation study to select a liposome composition for in vitro test. Five different liposome (LP) formulations, composed of phosphatidyl choline, cholesterol and charged surfactant (2:1:1, molar ratio) have been prepared by direct hydration and extrusion. As charged surfactants dicetyl phosphate didecyldimethylammonium chloride, di isobutyl phenoxy ethyl dimethyl benzyl ammonium chloride and stearylamine (SA) and have been used. Liposome charge, size and morphology were investigated by zeta potential, photon correlation spectroscopy, small angle x-ray spectroscopy and electron microscopy. LP-SA was selected for the loading of biofilm inhibitors and subjected to high performance liquid chromatography for entrapment capacity evaluation. LP-SA loaded inhibitors showed a higher diameter (223.6 nm) as compared to unloaded ones (205.7 nm) and a dose-dependent anti-biofilm effect mainly after 48 h of treatment, while free biofilm inhibitors loose activity. In conclusion, our data supported the use of liposomes as a strategy to enhance biofilm inhibitors effect." @default.
- W3107156932 created "2020-12-07" @default.
- W3107156932 creator A5003258116 @default.
- W3107156932 creator A5017653359 @default.
- W3107156932 creator A5023552442 @default.
- W3107156932 creator A5034514549 @default.
- W3107156932 creator A5036652389 @default.
- W3107156932 creator A5042526827 @default.
- W3107156932 creator A5069510824 @default.
- W3107156932 creator A5076179615 @default.
- W3107156932 creator A5090301094 @default.
- W3107156932 date "2020-11-30" @default.
- W3107156932 modified "2023-09-27" @default.
- W3107156932 title "Design of Nanosystems for the Delivery of Quorum Sensing Inhibitors: A Preliminary Study" @default.
- W3107156932 cites W1596251670 @default.
- W3107156932 cites W1973843350 @default.
- W3107156932 cites W1980057974 @default.
- W3107156932 cites W1987426048 @default.
- W3107156932 cites W2006157006 @default.
- W3107156932 cites W2007002493 @default.
- W3107156932 cites W2015178572 @default.
- W3107156932 cites W2021401450 @default.
- W3107156932 cites W2062521206 @default.
- W3107156932 cites W2069268247 @default.
- W3107156932 cites W2070300719 @default.
- W3107156932 cites W2085171353 @default.
- W3107156932 cites W2087851011 @default.
- W3107156932 cites W2112471324 @default.
- W3107156932 cites W2112487751 @default.
- W3107156932 cites W2118023881 @default.
- W3107156932 cites W2122836009 @default.
- W3107156932 cites W2127915306 @default.
- W3107156932 cites W2131230616 @default.
- W3107156932 cites W2138743700 @default.
- W3107156932 cites W2149664335 @default.
- W3107156932 cites W2163817676 @default.
- W3107156932 cites W2288546959 @default.
- W3107156932 cites W2300671107 @default.
- W3107156932 cites W2779019546 @default.
- W3107156932 cites W2889304661 @default.
- W3107156932 cites W2922273975 @default.
- W3107156932 cites W3023262506 @default.
- W3107156932 cites W4238244338 @default.
- W3107156932 cites W54782832 @default.
- W3107156932 doi "https://doi.org/10.3390/molecules25235655" @default.
- W3107156932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7730761" @default.
- W3107156932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33266241" @default.
- W3107156932 hasPublicationYear "2020" @default.
- W3107156932 type Work @default.
- W3107156932 sameAs 3107156932 @default.
- W3107156932 citedByCount "14" @default.
- W3107156932 countsByYear W31071569322021 @default.
- W3107156932 countsByYear W31071569322022 @default.
- W3107156932 countsByYear W31071569322023 @default.
- W3107156932 crossrefType "journal-article" @default.
- W3107156932 hasAuthorship W3107156932A5003258116 @default.
- W3107156932 hasAuthorship W3107156932A5017653359 @default.
- W3107156932 hasAuthorship W3107156932A5023552442 @default.
- W3107156932 hasAuthorship W3107156932A5034514549 @default.
- W3107156932 hasAuthorship W3107156932A5036652389 @default.
- W3107156932 hasAuthorship W3107156932A5042526827 @default.
- W3107156932 hasAuthorship W3107156932A5069510824 @default.
- W3107156932 hasAuthorship W3107156932A5076179615 @default.
- W3107156932 hasAuthorship W3107156932A5090301094 @default.
- W3107156932 hasBestOaLocation W31071569321 @default.
- W3107156932 hasConcept C118687296 @default.
- W3107156932 hasConcept C13965031 @default.
- W3107156932 hasConcept C155672457 @default.
- W3107156932 hasConcept C171250308 @default.
- W3107156932 hasConcept C178790620 @default.
- W3107156932 hasConcept C185154212 @default.
- W3107156932 hasConcept C185592680 @default.
- W3107156932 hasConcept C192562407 @default.
- W3107156932 hasConcept C2779660836 @default.
- W3107156932 hasConcept C43617362 @default.
- W3107156932 hasConcept C523546767 @default.
- W3107156932 hasConcept C54355233 @default.
- W3107156932 hasConcept C55493867 @default.
- W3107156932 hasConcept C58123911 @default.
- W3107156932 hasConcept C58226133 @default.
- W3107156932 hasConcept C86181022 @default.
- W3107156932 hasConcept C86803240 @default.
- W3107156932 hasConceptScore W3107156932C118687296 @default.
- W3107156932 hasConceptScore W3107156932C13965031 @default.
- W3107156932 hasConceptScore W3107156932C155672457 @default.
- W3107156932 hasConceptScore W3107156932C171250308 @default.
- W3107156932 hasConceptScore W3107156932C178790620 @default.
- W3107156932 hasConceptScore W3107156932C185154212 @default.
- W3107156932 hasConceptScore W3107156932C185592680 @default.
- W3107156932 hasConceptScore W3107156932C192562407 @default.
- W3107156932 hasConceptScore W3107156932C2779660836 @default.
- W3107156932 hasConceptScore W3107156932C43617362 @default.
- W3107156932 hasConceptScore W3107156932C523546767 @default.
- W3107156932 hasConceptScore W3107156932C54355233 @default.
- W3107156932 hasConceptScore W3107156932C55493867 @default.
- W3107156932 hasConceptScore W3107156932C58123911 @default.
- W3107156932 hasConceptScore W3107156932C58226133 @default.
- W3107156932 hasConceptScore W3107156932C86181022 @default.