Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107257957> ?p ?o ?g. }
- W3107257957 abstract "Synovitis is a major component of osteoarthritis and is driven primarily by macrophages. Synovial macrophages are crucial for joint homeostasis (M2-like phenotype), but induce inflammation (M1-like) when regulatory functions become overwhelmed. Macrophage phenotypes in synovium from osteoarthritic and healthy joints are poorly characterized; however, comparative knowledge of their phenotypes during health and disease is paramount for developing targeted treatments. This study compared patterns of macrophage activation in healthy and osteoarthritic equine synovium and correlated histology with cytokine/chemokine profiles in synovial fluid. Synovial histology and immunohistochemistry for M1-like (CD86), M2-like (CD206, IL-10), and pan macrophage (CD14) markers were performed on biopsies from 29 healthy and 26 osteoarthritic equine joints. Synovial fluid cytokines (MCP-1, IL-10, PGE 2 , IL-1β, IL-6, TNF-α, IL-1ra) and growth factors (GM-CSF, SDF-1α+β, IGF-1, and FGF-2) were quantified. Macrophage phenotypes were not as clearly defined in vivo as they are in vitro . All macrophage markers were expressed with minimal differences between OA and normal joints. Expression for all markers increased proportionate to synovial inflammation, especially CD86. Synovial fluid MCP-1 was higher in osteoarthritic joints while SDF-1 and IL-10 were lower, and PGE 2 concentrations did not differ between groups. Increased CD14/CD86/CD206/IL-10 expression was associated with synovial hyperplasia, consistent with macrophage recruitment and activation in response to injury. Lower synovial fluid IL-10 could suggest that homeostatic mechanisms from synovial macrophages became overwhelmed preventing inflammation resolution, resulting in chronic inflammation and OA. Further investigations into mechanisms of arthritis resolution are warranted. Developing pro-resolving therapies may provide superior results in the treatment of OA." @default.
- W3107257957 created "2020-12-07" @default.
- W3107257957 creator A5021128266 @default.
- W3107257957 creator A5026579525 @default.
- W3107257957 creator A5034189914 @default.
- W3107257957 creator A5038158693 @default.
- W3107257957 creator A5038522015 @default.
- W3107257957 creator A5038886456 @default.
- W3107257957 creator A5050919423 @default.
- W3107257957 creator A5090627936 @default.
- W3107257957 date "2020-11-26" @default.
- W3107257957 modified "2023-10-15" @default.
- W3107257957 title "Macrophage Activation in the Synovium of Healthy and Osteoarthritic Equine Joints" @default.
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