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- W3107264782 abstract "Immune checkpoint inhibitors (ICIs) represent one of the most promising therapeutic approaches in metastatic non-small cell lung cancer (M-NSCLC). Unfortunately, approximately 50–75% of patients do not respond to this treatment modality. Intratumor heterogeneity (ITH) at the genetic and phenotypic level is considered as a major cause of anticancer therapy failure, including resistance to ICIs. Recent observations suggest that spatial heterogeneity in the composition and spatial organization of the tumor microenvironment plays a major role in the response of M-NSCLC patients to ICIs. In this mini review, we first present a brief overview of the use of ICIs in M-NSCLC. We then discuss the role of genetic and non-genetic ITH on the efficacy of ICIs in patients with M-NSCLC." @default.
- W3107264782 created "2020-12-07" @default.
- W3107264782 creator A5011125993 @default.
- W3107264782 creator A5023250116 @default.
- W3107264782 creator A5079664149 @default.
- W3107264782 creator A5087508872 @default.
- W3107264782 date "2020-12-04" @default.
- W3107264782 modified "2023-10-16" @default.
- W3107264782 title "The Role of Intratumor Heterogeneity in the Response of Metastatic Non-Small Cell Lung Cancer to Immune Checkpoint Inhibitors" @default.
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- W3107264782 doi "https://doi.org/10.3389/fonc.2020.569202" @default.
- W3107264782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7746867" @default.
- W3107264782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33344229" @default.