Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107281569> ?p ?o ?g. }
- W3107281569 endingPage "3649" @default.
- W3107281569 startingPage "3649" @default.
- W3107281569 abstract "The role of Epigenetics in Epithelial Mesenchymal Transition (EMT) has recently emerged. Two epigenetic enzymes with paradoxical roles have previously been associated to EMT, EZH2 (Enhancer of Zeste 2 Polycomb Repressive Complex 2 (PRC2) Subunit), a lysine methyltranserase able to add the H3K27me3 mark, and the histone demethylase KDM6B (Lysine Demethylase 6B), which can remove the H3K27me3 mark. Nevertheless, it still remains unclear how these enzymes, with apparent opposite activities, could both promote EMT. In this study, we evaluated the function of these two enzymes using an EMT-inducible model, the lung cancer A549 cell line. ChIP-seq coupled with transcriptomic analysis showed that EZH2 and KDM6B were able to target and modulate the expression of different genes during EMT. Based on this analysis, we described INHBB, WTN5B, and ADAMTS6 as new EMT markers regulated by epigenetic modifications and directly implicated in EMT induction." @default.
- W3107281569 created "2020-12-07" @default.
- W3107281569 creator A5005580793 @default.
- W3107281569 creator A5013631172 @default.
- W3107281569 creator A5019906242 @default.
- W3107281569 creator A5021988484 @default.
- W3107281569 creator A5022288769 @default.
- W3107281569 creator A5029836197 @default.
- W3107281569 creator A5046180668 @default.
- W3107281569 creator A5050558912 @default.
- W3107281569 creator A5054833264 @default.
- W3107281569 creator A5064192864 @default.
- W3107281569 creator A5064872025 @default.
- W3107281569 creator A5074637174 @default.
- W3107281569 creator A5078237337 @default.
- W3107281569 creator A5088899598 @default.
- W3107281569 creator A5090988007 @default.
- W3107281569 date "2020-12-05" @default.
- W3107281569 modified "2023-10-17" @default.
- W3107281569 title "EZH2 and KDM6B Expressions Are Associated with Specific Epigenetic Signatures during EMT in Non Small Cell Lung Carcinomas" @default.
- W3107281569 cites W1515566746 @default.
- W3107281569 cites W1525058971 @default.
- W3107281569 cites W1802229300 @default.
- W3107281569 cites W1924787546 @default.
- W3107281569 cites W1978078849 @default.
- W3107281569 cites W1987348753 @default.
- W3107281569 cites W1998164580 @default.
- W3107281569 cites W2018905452 @default.
- W3107281569 cites W2076272265 @default.
- W3107281569 cites W2084006149 @default.
- W3107281569 cites W2104856326 @default.
- W3107281569 cites W2114708447 @default.
- W3107281569 cites W2117692326 @default.
- W3107281569 cites W2119382610 @default.
- W3107281569 cites W2126496132 @default.
- W3107281569 cites W2131071584 @default.
- W3107281569 cites W2154589460 @default.
- W3107281569 cites W2154860326 @default.
- W3107281569 cites W2161765786 @default.
- W3107281569 cites W2171608813 @default.
- W3107281569 cites W2176667622 @default.
- W3107281569 cites W2308485224 @default.
- W3107281569 cites W2519983303 @default.
- W3107281569 cites W2522404881 @default.
- W3107281569 cites W2528191425 @default.
- W3107281569 cites W2546492448 @default.
- W3107281569 cites W2567466771 @default.
- W3107281569 cites W2577055691 @default.
- W3107281569 cites W2616637751 @default.
- W3107281569 cites W2638401050 @default.
- W3107281569 cites W2734910575 @default.
- W3107281569 cites W2768269808 @default.
- W3107281569 cites W2784044161 @default.
- W3107281569 cites W2793137333 @default.
- W3107281569 cites W2794268606 @default.
- W3107281569 cites W2888945647 @default.
- W3107281569 cites W2890293509 @default.
- W3107281569 cites W2902947310 @default.
- W3107281569 cites W2905603102 @default.
- W3107281569 cites W2916837967 @default.
- W3107281569 cites W2970415876 @default.
- W3107281569 cites W3091125595 @default.
- W3107281569 doi "https://doi.org/10.3390/cancers12123649" @default.
- W3107281569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7762040" @default.
- W3107281569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33291363" @default.
- W3107281569 hasPublicationYear "2020" @default.
- W3107281569 type Work @default.
- W3107281569 sameAs 3107281569 @default.
- W3107281569 citedByCount "13" @default.
- W3107281569 countsByYear W31072815692021 @default.
- W3107281569 countsByYear W31072815692022 @default.
- W3107281569 countsByYear W31072815692023 @default.
- W3107281569 crossrefType "journal-article" @default.
- W3107281569 hasAuthorship W3107281569A5005580793 @default.
- W3107281569 hasAuthorship W3107281569A5013631172 @default.
- W3107281569 hasAuthorship W3107281569A5019906242 @default.
- W3107281569 hasAuthorship W3107281569A5021988484 @default.
- W3107281569 hasAuthorship W3107281569A5022288769 @default.
- W3107281569 hasAuthorship W3107281569A5029836197 @default.
- W3107281569 hasAuthorship W3107281569A5046180668 @default.
- W3107281569 hasAuthorship W3107281569A5050558912 @default.
- W3107281569 hasAuthorship W3107281569A5054833264 @default.
- W3107281569 hasAuthorship W3107281569A5064192864 @default.
- W3107281569 hasAuthorship W3107281569A5064872025 @default.
- W3107281569 hasAuthorship W3107281569A5074637174 @default.
- W3107281569 hasAuthorship W3107281569A5078237337 @default.
- W3107281569 hasAuthorship W3107281569A5088899598 @default.
- W3107281569 hasAuthorship W3107281569A5090988007 @default.
- W3107281569 hasBestOaLocation W31072815691 @default.
- W3107281569 hasConcept C101762097 @default.
- W3107281569 hasConcept C104317684 @default.
- W3107281569 hasConcept C150194340 @default.
- W3107281569 hasConcept C194232998 @default.
- W3107281569 hasConcept C2776745794 @default.
- W3107281569 hasConcept C2776915012 @default.
- W3107281569 hasConcept C2780914512 @default.
- W3107281569 hasConcept C2781364455 @default.
- W3107281569 hasConcept C41091548 @default.