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- W3107366986 abstract "DNA segments coding for the amino terminal and carboxyl terminal half of immunoglobulin chains are separate in an embryo, and there occurs specific rearrangement in these DNA segments during differentiation of lymphocytes. While the simplest model would be that the rearrangement brings a V-gene in contiguity with a C-gene, thereby allowing RNA polymerase to transcribe a whole immunoglobulin gene continuously, it has not been directly shown that this is really the case. This chapter presents evidence that shows that variable and constant parts of immunoglobulin light-chain gene of a mouse myeloma cell are separated by a nontranslated spacer. The chapter presents an experiment in which DNA was hybridized from a plasmacytoma with a purified light chain mRNA under conditions that would not permit renaturation of the gene segments. The conditions needed to be such that would digest all single-stranded nucleic acids with single strand specific nuclease S 1 and that would determine the size of the DNA segment protected by the mRNA from digestion with S 1 nuclease. The results indicated that the ϰ-mRNA from MOPC 321 myeloma contains stretches of polynucleotides that are transcribed from two DNA segments of about equal length that lie separate in the genome." @default.
- W3107366986 created "2020-12-07" @default.
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- W3107366986 date "1979-01-01" @default.
- W3107366986 modified "2023-09-27" @default.
- W3107366986 title "V- AND C-PARTS OF IMMUNOGLOBULIN n-CHAIN GENES ARE SEPARATE IN MYELOMA" @default.
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- W3107366986 doi "https://doi.org/10.1016/b978-0-12-569650-0.50021-8" @default.
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