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- W3107400017 abstract "The interleukin-4 (IL-4) receptor is expressed at high levels by a wide range of tumors, including non-small cell lung carcinoma, pancreatic carcinoma, head and neck carcinoma, prostate carcinoma, and malignant glioma. The IL-4 receptor (IL-4R), therefore, has been considered as a novel target for cancer therapy. Using phage display, we have previously identified a peptide ligand with sequence of CRKRLDRNC (named AP-1) that binds to IL-4R. To address in vivo imaging of tumor, AP-1 and Cy7.5 near-infrared dye were conjugated to hydrophobically-modified glycol chitosan (HGC) nanoparticles. The HGC nanoparticles are composed of biodegradable polymer and 250 nm in diameter and have 15 peptides labeled on each particle. When intravenously injected into nude mice bearing IL-4R-expressing H226 lung tumor xenografts, AP-1-HGC-Cy7.5 nanoparticles homed to tumor and resulted in stronger near-infrared fluorescence signal at 2 h after injection, as compared to unlabeled HGC-Cy7.5 nanoparticles. To examine the peptide-directed tumor therapy, AP-1 was conjugated to liposomes containing doxorubicin (Lipo-Dox). Treatment of mice bearing H226 tumor with either Lipo-Dox or AP-1-Lipo-Dox (at the concentration of 1 mg doxorubicin/kg body weight; injected twice a week for total 8 times) significantly inhibited tumor growth as compared to saline- or doxorubicin-treated groups. Free doxorubicin given at the same concentration showed minimal inhibition of tumor growth. More importantly, AP-1-Lipo-Dox more efficiently inhibited tumor growth as compared to Lipo-Dox. These results suggest that AP-1, an IL-4-mimicking peptide ligand, can target IL-4R highly expressed on tumor cells and direct targeted delivery of imaging agents and therapeutics to tumor. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5016." @default.
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- W3107400017 date "2009-05-01" @default.
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- W3107400017 title "Abstract #5016: In vivo imaging and therapy of tumor by targeting interleukin-4 receptor" @default.
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