FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107450189> ?p ?o ?g. }

• W3107450189 abstract "Glioma is sensitive to microtubule-targeting agents (MTAs), but most MTAs do not cross the blood brain barrier (BBB). To address this limitation, we developed the new chemical entity, ST-401, a brain-penetrant MTA.Synthesis of ST-401. Measures of MT assembly and dynamics. Cell proliferation and viability of patient-derived (PD) glioma in culture. Measure of tumor microtube (TM) parameters using immunofluorescence analysis and machine learning-based workflow. Pharmacokinetics (PK) and experimental toxicity in mice. In vivo antitumor activity in the RCAS/tv-a PDGFB-driven glioma (PDGFB-glioma) mouse model.We discovered that ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 inhibits the formation of TMs, MT-rich structures that connect glioma to a network that promotes resistance to DNA damage. PK analysis of ST-401 in mice shows brain penetration reaching antitumor concentrations, and in vivo testing of ST-401 in a xenograft flank tumor mouse model demonstrates significant antitumor activity and no over toxicity in mice. In the PDGFB-glioma mouse model, ST-401 enhances the therapeutic efficacies of temozolomide (TMZ) and radiation therapy (RT).Our study identifies hallmarks of glioma tumorigenesis that are sensitive to MTAs and reports ST-401 as a promising chemical scaffold to develop brain-penetrant MTAs." @default.
• W3107450189 created "2020-12-07" @default.
• W3107450189 creator A5002605353 @default.
• W3107450189 creator A5005134904 @default.
• W3107450189 creator A5011103119 @default.
• W3107450189 creator A5015751318 @default.
• W3107450189 creator A5021793523 @default.
• W3107450189 creator A5033194021 @default.
• W3107450189 creator A5033321629 @default.
• W3107450189 creator A5033683673 @default.
• W3107450189 creator A5038158464 @default.
• W3107450189 creator A5076104674 @default.
• W3107450189 creator A5080622852 @default.
• W3107450189 creator A5084697894 @default.
• W3107450189 creator A5088149477 @default.
• W3107450189 creator A5089584085 @default.
• W3107450189 date "2020-12-03" @default.
• W3107450189 modified "2023-10-15" @default.
• W3107450189 title "A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis" @default.
• W3107450189 cites W1910209889 @default.
• W3107450189 cites W1940274322 @default.
• W3107450189 cites W1973944247 @default.
• W3107450189 cites W1982746572 @default.
• W3107450189 cites W1988963409 @default.
• W3107450189 cites W1994406643 @default.
• W3107450189 cites W2027102742 @default.
• W3107450189 cites W2040674278 @default.
• W3107450189 cites W2070835985 @default.
• W3107450189 cites W2101006499 @default.
• W3107450189 cites W2105916176 @default.
• W3107450189 cites W2109816625 @default.
• W3107450189 cites W2112050795 @default.
• W3107450189 cites W2123369892 @default.
• W3107450189 cites W2128130529 @default.
• W3107450189 cites W2139183953 @default.
• W3107450189 cites W2202001486 @default.
• W3107450189 cites W2237916396 @default.
• W3107450189 cites W2463405380 @default.
• W3107450189 cites W2474649469 @default.
• W3107450189 cites W2605795763 @default.
• W3107450189 cites W2626629374 @default.
• W3107450189 cites W2767607515 @default.
• W3107450189 cites W2768811915 @default.
• W3107450189 cites W2796572741 @default.
• W3107450189 cites W2799809717 @default.
• W3107450189 cites W2806574348 @default.
• W3107450189 cites W2890109436 @default.
• W3107450189 cites W2922854104 @default.
• W3107450189 cites W2924119503 @default.
• W3107450189 cites W2965742180 @default.
• W3107450189 cites W2975634117 @default.
• W3107450189 cites W2989153544 @default.
• W3107450189 cites W2994004185 @default.
• W3107450189 cites W3023290436 @default.
• W3107450189 doi "https://doi.org/10.1093/noajnl/vdaa165" @default.
• W3107450189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7813200" @default.
• W3107450189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33506204" @default.
• W3107450189 hasPublicationYear "2020" @default.
• W3107450189 type Work @default.
• W3107450189 sameAs 3107450189 @default.
• W3107450189 citedByCount "7" @default.
• W3107450189 countsByYear W31074501892021 @default.
• W3107450189 countsByYear W31074501892022 @default.
• W3107450189 countsByYear W31074501892023 @default.
• W3107450189 crossrefType "journal-article" @default.
• W3107450189 hasAuthorship W3107450189A5002605353 @default.
• W3107450189 hasAuthorship W3107450189A5005134904 @default.
• W3107450189 hasAuthorship W3107450189A5011103119 @default.
• W3107450189 hasAuthorship W3107450189A5015751318 @default.
• W3107450189 hasAuthorship W3107450189A5021793523 @default.
• W3107450189 hasAuthorship W3107450189A5033194021 @default.
• W3107450189 hasAuthorship W3107450189A5033321629 @default.
• W3107450189 hasAuthorship W3107450189A5033683673 @default.
• W3107450189 hasAuthorship W3107450189A5038158464 @default.
• W3107450189 hasAuthorship W3107450189A5076104674 @default.
• W3107450189 hasAuthorship W3107450189A5080622852 @default.
• W3107450189 hasAuthorship W3107450189A5084697894 @default.
• W3107450189 hasAuthorship W3107450189A5088149477 @default.
• W3107450189 hasAuthorship W3107450189A5089584085 @default.
• W3107450189 hasBestOaLocation W31074501891 @default.
• W3107450189 hasConcept C150903083 @default.
• W3107450189 hasConcept C169760540 @default.
• W3107450189 hasConcept C185592680 @default.
• W3107450189 hasConcept C207001950 @default.
• W3107450189 hasConcept C2778227246 @default.
• W3107450189 hasConcept C2778402981 @default.
• W3107450189 hasConcept C502942594 @default.
• W3107450189 hasConcept C529278444 @default.
• W3107450189 hasConcept C86803240 @default.
• W3107450189 hasConcept C98274493 @default.
• W3107450189 hasConceptScore W3107450189C150903083 @default.
• W3107450189 hasConceptScore W3107450189C169760540 @default.
• W3107450189 hasConceptScore W3107450189C185592680 @default.
• W3107450189 hasConceptScore W3107450189C207001950 @default.
• W3107450189 hasConceptScore W3107450189C2778227246 @default.
• W3107450189 hasConceptScore W3107450189C2778402981 @default.
• W3107450189 hasConceptScore W3107450189C502942594 @default.
• W3107450189 hasConceptScore W3107450189C529278444 @default.
• W3107450189 hasConceptScore W3107450189C86803240 @default.
• W3107450189 hasConceptScore W3107450189C98274493 @default.

• next