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• W3107547143 abstract "Abstract Background Cerebrospinal fluid (CSF) flow in disease has been investigated with two‐dimensional (2D) phase‐contrast magnetic resonance imaging (PC‐MRI) in humans. Despite similar diseases occurring in dogs, PC‐MRI is not routinely performed and CSF flow and its association with diseases is poorly understood. Objectives To adapt 2D and four‐dimensional (4D) PC‐MRI to dogs and to apply them in a group of neurologically healthy dogs. Animals Six adult Beagle dogs of a research colony. Methods Prospective, experimental study. Sequences were first optimized on a phantom mimicking small CSF spaces and low velocity flow. Then, 4D PC‐MRI and 2D PC‐MRI at the level of the mesencephalic aqueduct, foramen magnum (FM), and cervical spine were performed. Results CSF displayed a bidirectional flow pattern on 2D PC‐MRI at each location. Mean peak velocity (and range) in cm/s was 0.92 (0.51‐2.08) within the mesencephalic aqueduct, 1.84 (0.89‐2.73) and 1.17 (0.75‐1.8) in the ventral and dorsal subarachnoid space (SAS) at the FM, and 2.03 (range 1.1‐3.0) and 1.27 (range 0.96‐1.82) within the ventral and dorsal SAS of the cervical spine. With 4D PC‐MRI, flow velocities of >3 cm/s were visualized in the phantom, but no flow data were obtained in dogs. Conclusion Peak flow velocities were measured with 2D PC‐MRI at all 3 locations and slower velocities were recorded in healthy Beagle dogs compared to humans. These values serve as baseline for future applications. The current technical settings did not allow measurement of CSF flow in Beagle dogs by 4D PC‐MRI." @default.
• W3107547143 created "2020-12-07" @default.
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• W3107547143 date "2020-12-04" @default.
• W3107547143 modified "2023-10-06" @default.
• W3107547143 title "Quantification of cerebrospinal fluid flow in dogs by cardiac‐gated phase‐contrast magnetic resonance imaging" @default.
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• W3107547143 doi "https://doi.org/10.1111/jvim.15932" @default.
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