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• W3107547321 endingPage "108560" @default.
• W3107547321 startingPage "108560" @default.
• W3107547321 abstract "Targeting pathogenic immune cell trafficking poses an attractive opportunity to attenuate autoimmune disorders such as multiple sclerosis (MS). MS and its animal model, experimental autoimmune encephalomyelitis (EAE), are characterized by the immune cells-mediated demyelination and neurodegeneration of the central nervous system (CNS). Our previous study has proven that dietary naringenin ameliorates EAE clinical symptoms via reducing the CNS cell infiltration. The present study examined the beneficial effects of naringenin on maintaining the blood-brain barrier in EAE mice via dietary naringenin intervention. The results showed that naringenin-treated EAE mice had an intact blood-CNS barrier by increasing tight junction-associated factors and decreasing Evans Blue dye in the CNS. Naringenin decreased the accumulation and maturation of conventional dendritic cells (cDCs), CCL19, and CCR7 in the CNS. Also, naringenin blocked the chemotaxis and antigen-presenting function of cDCs that resulted in reducing T-cell secreting cytokines (IFN-γ, IL-17, and IL-6) in the spleen. Importantly, naringenin blocked pathogenic T cells infiltrated into the CNS and attenuates passive EAE. Therefore, by blocking chemokine-mediated migration of DCs and pathogenic T cells into the CNS, naringenin attenuates EAE pathogenesis and might be a potential candidate for the treatment of autoimmune diseases, such as MS and other chronic T-cell mediated autoimmune diseases." @default.
• W3107547321 created "2020-12-07" @default.
• W3107547321 creator A5006874004 @default.
• W3107547321 creator A5034226931 @default.
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• W3107547321 date "2021-03-01" @default.
• W3107547321 modified "2023-09-29" @default.
• W3107547321 title "Naringenin attenuates experimental autoimmune encephalomyelitis by protecting the intact of blood-brain barrier and controlling inflammatory cell migration" @default.
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• W3107547321 doi "https://doi.org/10.1016/j.jnutbio.2020.108560" @default.
• W3107547321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33249188" @default.
• W3107547321 hasPublicationYear "2021" @default.
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