FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107552445> ?p ?o ?g. }

• W3107552445 endingPage "120145" @default.
• W3107552445 startingPage "120145" @default.
• W3107552445 abstract "Current treatment for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) involves transvaginal implantation of surgical mesh, conventionally made of polypropylene (PP). However, it has recently become apparent that the mechanical properties of PP are unsuitable, resulting in serious complications such as tissue erosion. In this study, thermoplastic polyurethane (TPU) was chosen as an alternative material, and hormone-loaded meshes were produced by fused deposition modelling (FDM). Filaments containing various concentrations (0%, 0.25%, 1%) of 17-β-estradiol (E2) were prepared by hot-melt extrusion (HME) and were 3D printed into meshes with various geometries. The resulting meshes were characterised through a variety of instruments such as attenuated total reflection-Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), thermal analysis, fracture force and in vitro release studies. The results showed that E2 was homogeneously distributed throughout the TPU matrix. Moreover, the thermogravimetric analysis (TGA) showed degradation temperatures above those used during the FDM process, showing that the meshes can be produced below the degradation temperatures of the materials. The fracture force testing showed that material and mesh geometry influence mechanical properties, with TPU meshes appearing more elastic and therefore more suitable for pelvic floor repair than PP mesh. However, interestingly the mechanical properties of the TPU70 filament was not affected by the inclusion of E2. In addition, the 3D printed meshes showed a linear E2 release profile over a two weeks period, which can be modified according to the percentage of E2 added to the 3D printed construct. This proof of concept study demonstrates the potential of using FDM to create a new generation of safer mesh implants." @default.
• W3107552445 created "2020-12-07" @default.
• W3107552445 creator A5000110917 @default.
• W3107552445 creator A5001311671 @default.
• W3107552445 creator A5004921237 @default.
• W3107552445 creator A5017939708 @default.
• W3107552445 creator A5024238182 @default.
• W3107552445 creator A5081547013 @default.
• W3107552445 creator A5090970915 @default.
• W3107552445 date "2021-01-01" @default.
• W3107552445 modified "2023-10-06" @default.
• W3107552445 title "3D printed estradiol-eluting urogynecological mesh implants: Influence of material and mesh geometry on their mechanical properties" @default.
• W3107552445 cites W1882523267 @default.
• W3107552445 cites W2011900238 @default.
• W3107552445 cites W2018435317 @default.
• W3107552445 cites W2054294448 @default.
• W3107552445 cites W2056563583 @default.
• W3107552445 cites W2087578685 @default.
• W3107552445 cites W2158623340 @default.
• W3107552445 cites W2194034177 @default.
• W3107552445 cites W2277745662 @default.
• W3107552445 cites W2301320533 @default.
• W3107552445 cites W2519746511 @default.
• W3107552445 cites W2527819080 @default.
• W3107552445 cites W2605510108 @default.
• W3107552445 cites W2620842343 @default.
• W3107552445 cites W2745078986 @default.
• W3107552445 cites W2775081252 @default.
• W3107552445 cites W2792712540 @default.
• W3107552445 cites W2806937348 @default.
• W3107552445 cites W2898464641 @default.
• W3107552445 cites W2903613218 @default.
• W3107552445 cites W2912308484 @default.
• W3107552445 cites W2928062382 @default.
• W3107552445 cites W2940557726 @default.
• W3107552445 cites W2948324539 @default.
• W3107552445 cites W2967464127 @default.
• W3107552445 cites W2968484150 @default.
• W3107552445 cites W2976211492 @default.
• W3107552445 cites W2999646644 @default.
• W3107552445 cites W3034579606 @default.
• W3107552445 cites W3042251649 @default.
• W3107552445 doi "https://doi.org/10.1016/j.ijpharm.2020.120145" @default.
• W3107552445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33309830" @default.
• W3107552445 hasPublicationYear "2021" @default.
• W3107552445 type Work @default.
• W3107552445 sameAs 3107552445 @default.
• W3107552445 citedByCount "37" @default.
• W3107552445 countsByYear W31075524452021 @default.
• W3107552445 countsByYear W31075524452022 @default.
• W3107552445 countsByYear W31075524452023 @default.
• W3107552445 crossrefType "journal-article" @default.
• W3107552445 hasAuthorship W3107552445A5000110917 @default.
• W3107552445 hasAuthorship W3107552445A5001311671 @default.
• W3107552445 hasAuthorship W3107552445A5004921237 @default.
• W3107552445 hasAuthorship W3107552445A5017939708 @default.
• W3107552445 hasAuthorship W3107552445A5024238182 @default.
• W3107552445 hasAuthorship W3107552445A5081547013 @default.
• W3107552445 hasAuthorship W3107552445A5090970915 @default.
• W3107552445 hasBestOaLocation W31075524452 @default.
• W3107552445 hasConcept C127413603 @default.
• W3107552445 hasConcept C136229726 @default.
• W3107552445 hasConcept C159985019 @default.
• W3107552445 hasConcept C160892712 @default.
• W3107552445 hasConcept C178790620 @default.
• W3107552445 hasConcept C185592680 @default.
• W3107552445 hasConcept C192562407 @default.
• W3107552445 hasConcept C2524010 @default.
• W3107552445 hasConcept C26771246 @default.
• W3107552445 hasConcept C2777973245 @default.
• W3107552445 hasConcept C31487907 @default.
• W3107552445 hasConcept C33923547 @default.
• W3107552445 hasConcept C42360764 @default.
• W3107552445 hasConcept C60100273 @default.
• W3107552445 hasConcept C71924100 @default.
• W3107552445 hasConceptScore W3107552445C127413603 @default.
• W3107552445 hasConceptScore W3107552445C136229726 @default.
• W3107552445 hasConceptScore W3107552445C159985019 @default.
• W3107552445 hasConceptScore W3107552445C160892712 @default.
• W3107552445 hasConceptScore W3107552445C178790620 @default.
• W3107552445 hasConceptScore W3107552445C185592680 @default.
• W3107552445 hasConceptScore W3107552445C192562407 @default.
• W3107552445 hasConceptScore W3107552445C2524010 @default.
• W3107552445 hasConceptScore W3107552445C26771246 @default.
• W3107552445 hasConceptScore W3107552445C2777973245 @default.
• W3107552445 hasConceptScore W3107552445C31487907 @default.
• W3107552445 hasConceptScore W3107552445C33923547 @default.
• W3107552445 hasConceptScore W3107552445C42360764 @default.
• W3107552445 hasConceptScore W3107552445C60100273 @default.
• W3107552445 hasConceptScore W3107552445C71924100 @default.
• W3107552445 hasLocation W31075524451 @default.
• W3107552445 hasLocation W31075524452 @default.
• W3107552445 hasOpenAccess W3107552445 @default.
• W3107552445 hasPrimaryLocation W31075524451 @default.
• W3107552445 hasRelatedWork W1512319868 @default.
• W3107552445 hasRelatedWork W1974318772 @default.
• W3107552445 hasRelatedWork W2028308783 @default.
• W3107552445 hasRelatedWork W2079852693 @default.

• next