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- W3107630432 endingPage "9208" @default.
- W3107630432 startingPage "9208" @default.
- W3107630432 abstract "Studies on the cellular prion protein (PrPC) have been actively conducted because misfolded PrPC is known to cause transmissible spongiform encephalopathies or prion disease. PrPC is a glycophosphatidylinositol-anchored cell surface glycoprotein that has been reported to affect several cellular functions such as stress protection, cellular differentiation, mitochondrial homeostasis, circadian rhythm, myelin homeostasis, and immune modulation. Recently, it has also been reported that PrPC mediates tumor progression by enhancing the proliferation, metastasis, and drug resistance of cancer cells. In addition, PrPC regulates cancer stem cell properties by interacting with cancer stem cell marker proteins. In this review, we summarize how PrPC promotes tumor progression in terms of proliferation, metastasis, drug resistance, and cancer stem cell properties. In addition, we discuss strategies to treat tumors by modulating the function and expression of PrPC via the regulation of HSPA1L/HIF-1α expression and using an anti-prion antibody." @default.
- W3107630432 created "2020-12-07" @default.
- W3107630432 creator A5027464971 @default.
- W3107630432 creator A5076209952 @default.
- W3107630432 date "2020-12-02" @default.
- W3107630432 modified "2023-09-26" @default.
- W3107630432 title "The Cellular Prion Protein: A Promising Therapeutic Target for Cancer" @default.
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