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• W3107649994 endingPage "975" @default.
• W3107649994 startingPage "975" @default.
• W3107649994 abstract "Nematodes constitute a very successful phylum, especially in terms of parasitism. Inside their mammalian hosts, parasitic nematodes mainly dwell in the digestive tract (geohelminths) or in the vascular system (filariae). One of their main characteristics is their long sojourn inside the body where they are accessible to the immune system. Several strategies are used by parasites in order to counteract the immune attacks. One of them is the expression of molecules interfering with the function of the immune system. Excretory-secretory products (ESPs) pertain to this category. This is, however, not their only biological function, as they seem also involved in other mechanisms such as pathogenicity or parasitic cycle (molting, for example). We will mainly focus on filariae ESPs with an emphasis on data available regarding Onchocerca volvulus, but we will also refer to a few relevant/illustrative examples related to other worm categories when necessary (geohelminth nematodes, trematodes or cestodes). We first present Onchocerca volvulus, mainly focusing on the aspects of this organism that seem relevant when it comes to ESPs: life cycle, manifestations of the sickness, immunosuppression, diagnosis and treatment. We then elaborate on the function and use of ESPs in these aspects." @default.
• W3107649994 created "2020-12-07" @default.
• W3107649994 creator A5029628855 @default.
• W3107649994 creator A5047764521 @default.
• W3107649994 creator A5059690322 @default.
• W3107649994 creator A5066845627 @default.
• W3107649994 date "2020-11-23" @default.
• W3107649994 modified "2023-09-23" @default.
• W3107649994 title "The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca volvulus Excretory Secretory Products" @default.
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