FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107680336> ?p ?o ?g. }

• W3107680336 abstract "Compound-protein pairs dominate FDA-approved drug-target pairs and the prediction of compound-protein affinity and contact (CPAC) could help accelerate drug discovery. In this study we consider proteins as multi-modal data including 1D amino-acid sequences and (sequence-predicted) 2D residue-pair contact maps. We empirically evaluate the embeddings of the two single modalities in their accuracy and generalizability of CPAC prediction (i.e. structure-free interpretable compound-protein affinity prediction). And we rationalize their performances in both challenges of embedding individual modalities and learning generalizable embedding-label relationship. We further propose two models involving cross-modality protein embedding and establish that the one with cross interaction (thus capturing correlations among modalities) outperforms SOTAs and our single modality models in affinity, contact, and binding-site predictions for proteins never seen in the training set." @default.
• W3107680336 created "2020-12-07" @default.
• W3107680336 creator A5004090047 @default.
• W3107680336 creator A5057485825 @default.
• W3107680336 date "2020-11-13" @default.
• W3107680336 modified "2023-09-26" @default.
• W3107680336 title "Cross-Modality Protein Embedding for Compound-Protein Affinity and Contact Prediction" @default.
• W3107680336 cites W1895993106 @default.
• W3107680336 cites W2096864392 @default.
• W3107680336 cites W2099257174 @default.
• W3107680336 cites W2114162221 @default.
• W3107680336 cites W2166550586 @default.
• W3107680336 cites W2604306554 @default.
• W3107680336 cites W2624431344 @default.
• W3107680336 cites W2751476102 @default.
• W3107680336 cites W2766453196 @default.
• W3107680336 cites W2784213390 @default.
• W3107680336 cites W2807792492 @default.
• W3107680336 cites W2809216727 @default.
• W3107680336 cites W2860192827 @default.
• W3107680336 cites W2894175828 @default.
• W3107680336 cites W2949867299 @default.
• W3107680336 cites W2962767366 @default.
• W3107680336 cites W2969862959 @default.
• W3107680336 cites W2969996838 @default.
• W3107680336 cites W2978484973 @default.
• W3107680336 cites W2996782940 @default.
• W3107680336 cites W2997034963 @default.
• W3107680336 cites W3007913141 @default.
• W3107680336 cites W3019745511 @default.
• W3107680336 cites W3032123378 @default.
• W3107680336 cites W3034604293 @default.
• W3107680336 cites W3035065454 @default.
• W3107680336 cites W3042770487 @default.
• W3107680336 cites W3102419180 @default.
• W3107680336 cites W3111218397 @default.
• W3107680336 doi "https://doi.org/10.48550/arxiv.2012.00651" @default.
• W3107680336 hasPublicationYear "2020" @default.
• W3107680336 type Work @default.
• W3107680336 sameAs 3107680336 @default.
• W3107680336 citedByCount "1" @default.
• W3107680336 countsByYear W31076803362021 @default.
• W3107680336 crossrefType "posted-content" @default.
• W3107680336 hasAuthorship W3107680336A5004090047 @default.
• W3107680336 hasAuthorship W3107680336A5057485825 @default.
• W3107680336 hasBestOaLocation W31076803361 @default.
• W3107680336 hasConcept C105795698 @default.
• W3107680336 hasConcept C119857082 @default.
• W3107680336 hasConcept C136886441 @default.
• W3107680336 hasConcept C144024400 @default.
• W3107680336 hasConcept C154945302 @default.
• W3107680336 hasConcept C185592680 @default.
• W3107680336 hasConcept C188027245 @default.
• W3107680336 hasConcept C19165224 @default.
• W3107680336 hasConcept C27158222 @default.
• W3107680336 hasConcept C2779903281 @default.
• W3107680336 hasConcept C2780226545 @default.
• W3107680336 hasConcept C33923547 @default.
• W3107680336 hasConcept C36289849 @default.
• W3107680336 hasConcept C41008148 @default.
• W3107680336 hasConcept C41608201 @default.
• W3107680336 hasConcept C51632099 @default.
• W3107680336 hasConcept C70721500 @default.
• W3107680336 hasConcept C71139939 @default.
• W3107680336 hasConcept C86803240 @default.
• W3107680336 hasConceptScore W3107680336C105795698 @default.
• W3107680336 hasConceptScore W3107680336C119857082 @default.
• W3107680336 hasConceptScore W3107680336C136886441 @default.
• W3107680336 hasConceptScore W3107680336C144024400 @default.
• W3107680336 hasConceptScore W3107680336C154945302 @default.
• W3107680336 hasConceptScore W3107680336C185592680 @default.
• W3107680336 hasConceptScore W3107680336C188027245 @default.
• W3107680336 hasConceptScore W3107680336C19165224 @default.
• W3107680336 hasConceptScore W3107680336C27158222 @default.
• W3107680336 hasConceptScore W3107680336C2779903281 @default.
• W3107680336 hasConceptScore W3107680336C2780226545 @default.
• W3107680336 hasConceptScore W3107680336C33923547 @default.
• W3107680336 hasConceptScore W3107680336C36289849 @default.
• W3107680336 hasConceptScore W3107680336C41008148 @default.
• W3107680336 hasConceptScore W3107680336C41608201 @default.
• W3107680336 hasConceptScore W3107680336C51632099 @default.
• W3107680336 hasConceptScore W3107680336C70721500 @default.
• W3107680336 hasConceptScore W3107680336C71139939 @default.
• W3107680336 hasConceptScore W3107680336C86803240 @default.
• W3107680336 hasLocation W31076803361 @default.
• W3107680336 hasLocation W31076803362 @default.
• W3107680336 hasOpenAccess W3107680336 @default.
• W3107680336 hasPrimaryLocation W31076803361 @default.
• W3107680336 hasRelatedWork W10719664 @default.
• W3107680336 hasRelatedWork W10980763 @default.
• W3107680336 hasRelatedWork W11122729 @default.
• W3107680336 hasRelatedWork W11356396 @default.
• W3107680336 hasRelatedWork W12940689 @default.
• W3107680336 hasRelatedWork W13034104 @default.
• W3107680336 hasRelatedWork W351505 @default.
• W3107680336 hasRelatedWork W7655147 @default.
• W3107680336 hasRelatedWork W8219677 @default.
• W3107680336 hasRelatedWork W8503766 @default.
• W3107680336 isParatext "false" @default.
• W3107680336 isRetracted "false" @default.

• next