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- W3107700172 abstract "Bowen disease (BD) is synonymous with squamous cell caricinoma in situ (SCCIS) of nongenital skin regions. Human papillomavirus (HPV) infection is one of the known etiological factors of BD. However, in previous studies, the detection rate of HPV in BD greatly varies from 0% to 83%, depending on DNA detection methods and study papulation’s characteristics. The objective of this study was to detect HPV DNA in BD samples using Ezplex HPV next generation sequencing (NGS) technique, which can detect 100 types of HPV. DNA was extracted from representative formalin-fixed and paraffin embedded (FFPE) tissue block of patients who was histopathologically confirmed as BD. In addition, we compared HPV profiles between pelvic and non-pelvic BD suspecting that detected HPV types in pelvic BD will predominantly be mucosal types, which is known to be sexually transmitted. FFPE tissue from 99 patients were studied. HPV was detected in 26 (26.3%) BD samples. 10 types of a-HPV genotypes was detected: HPV 16, 53, 31, 58, 66, 26, 27, 57, 45, and 72. The most common HPV type was 16 (12 patients, 12.1%). HPV detection rate was significantly higher in pelvic BDs (45.2%) compared with non-pelvic BDs (17.6%). In specific, mucosal a-HPV was detected significantly more often in pelvic BD (45.2%) compared with non-pelvic BD (14.7%). To our knowledge, this is the first study to use NGS technique in HPV detection in BD samples. The HPV detection rate, especially mucosal types, was higher in pelvic area. This study indicate the possible role of sexually transmitted mucosal HPVs to pathogenesis of BDs, especially in pelvic area." @default.
- W3107700172 created "2020-12-07" @default.
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- W3107700172 date "2020-12-01" @default.
- W3107700172 modified "2023-09-23" @default.
- W3107700172 title "14233 Higher human papillomavirus detection in Bowen disease in the pelvic area compared with the non-pelvic area: A retrospective study" @default.
- W3107700172 doi "https://doi.org/10.1016/j.jaad.2020.06.623" @default.
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