FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107708185> ?p ?o ?g. }

• W3107708185 endingPage "586" @default.
• W3107708185 startingPage "571" @default.
• W3107708185 abstract "Abstract STUDY QUESTION What is the physiological extent of vascular remodelling in and trophoblast plugging of the uterine circulation across the first half of pregnancy? SUMMARY ANSWER All levels of the uterine vascular tree (arcuate, radial and spiral arteries (SAs)) dilate ∼2.6- to 4.3-fold between 6 and 20 weeks of gestation, with significant aggregates of trophoblasts persisting in the decidual and myometrial parts of SAs beyond the first trimester. WHAT IS KNOWN ALREADY In early pregnancy, endovascular trophoblasts form ‘plugs’ in the SAs, transiently inhibiting blood flow to the placenta, whilst concurrently the uterine vasculature undergoes significant adaption to facilitate increased blood delivery to the placenta later in gestation. These processes are impaired in pregnancy disorders, but quantitative understanding of the anatomical changes even in normal pregnancy is poor. STUDY DESIGN, SIZE, DURATION Serial sections of normal placentae in situ (n = 22) of 6.1–20.5 weeks of gestation from the Boyd collection and Dixon collection (University of Cambridge, UK) were digitalized using a slide scanner or Axio Imager.A1 microscope. PARTICIPANTS/MATERIALS, SETTING, METHODS Spiral (n = 45), radial (n = 40) and arcuate (n = 39) arteries were manually segmented. Using custom-written scripts for Matlab® software, artery dimensions (Feret diameters; major axes; luminal/wall area) and endovascular trophoblast plug/aggregate (n = 24) porosities were calculated. Diameters of junctional zone SAs within the myometrium (n = 35) were acquired separately using a micrometre and light microscope. Decidual thickness and trophoblast plug depth was measured using ImageJ. MAIN RESULTS AND THE ROLE OF CHANCE By all measures, radial and arcuate artery dimensions progressively increased from 6.1 to 20.5 weeks (P &lt; 0.01). The greatest increase in SA calibre occurred after 12 weeks of gestation. Trophoblast aggregates were found to persist within decidual and myometrial parts of SA lumens beyond the first trimester, and up to 18.5 weeks of gestation, although those present in the second trimester did not appear to prevent the passage of red blood cells to the intervillous space. Trophoblasts forming these aggregates became more compact (decreased in porosity) over gestation, whilst channel size between cells increased (P = 0.01). Decidual thickness decreased linearly over gestation (P = 0.0003), meaning plugs occupied an increasing proportion of the decidua (P = 0.02). LARGE SCALE DATA N/A. LIMITATIONS, REASONS FOR CAUTION Although serial sections were assessed, two-dimensional images cannot completely reflect the three-dimensional properties and connectivity of vessels and plugs/aggregates. Immersion-fixation of the specimens means that vessel size may be under-estimated. WIDER IMPLICATIONS OF THE FINDINGS Uterine vascular remodelling and trophoblast plug dispersion is a progressive phenomenon that is not completed by the end of the first trimester. Our quantitative findings support the concept that radial arteries present a major site of resistance until mid-gestation. Their dimensional increase at 10–12 weeks of gestation may explain the rapid increase in blood flow to the placenta observed by others at ∼13 weeks. Measured properties of trophoblast plugs suggest that they will impact on the resistance, shear stress and nature of blood flow within the utero-placental vasculature until mid-gestation. The presence of channels within plugs will likely lead to high velocity flow streams and thus increase shear stress experienced by the trophoblasts forming the aggregates. Quantitative understanding of utero-placental vascular adaptation gained here will improve in silico modelling of utero-placental haemodynamics and provide new insights into pregnancy disorders, such as fetal growth restriction. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by a Royal Society Te Aparangi Marsden Grant [18-UOA-135]. A.R.C. is supported by a Rutherford Discovery Fellowship [14-UOA-019]. The authors have no conflict of interest to declare." @default.
• W3107708185 created "2020-12-07" @default.
• W3107708185 creator A5009699749 @default.
• W3107708185 creator A5013538627 @default.
• W3107708185 creator A5021269128 @default.
• W3107708185 creator A5021977829 @default.
• W3107708185 creator A5037670442 @default.
• W3107708185 creator A5066635614 @default.
• W3107708185 date "2020-12-02" @default.
• W3107708185 modified "2023-10-18" @default.
• W3107708185 title "Something old, something new: digital quantification of uterine vascular remodelling and trophoblast plugging in historical collections provides new insight into adaptation of the utero-placental circulation" @default.
• W3107708185 cites W1531505069 @default.
• W3107708185 cites W171819190 @default.
• W3107708185 cites W176871123 @default.
• W3107708185 cites W1843722888 @default.
• W3107708185 cites W1974465710 @default.
• W3107708185 cites W1975195151 @default.
• W3107708185 cites W1977233655 @default.
• W3107708185 cites W1981248992 @default.
• W3107708185 cites W1988820907 @default.
• W3107708185 cites W1992014298 @default.
• W3107708185 cites W2003269305 @default.
• W3107708185 cites W2006741262 @default.
• W3107708185 cites W2014979849 @default.
• W3107708185 cites W2019997266 @default.
• W3107708185 cites W2020837045 @default.
• W3107708185 cites W2035895394 @default.
• W3107708185 cites W2040613067 @default.
• W3107708185 cites W2045504362 @default.
• W3107708185 cites W2059264297 @default.
• W3107708185 cites W2067662349 @default.
• W3107708185 cites W2069993321 @default.
• W3107708185 cites W2071338376 @default.
• W3107708185 cites W2077311976 @default.
• W3107708185 cites W2089611230 @default.
• W3107708185 cites W2098034615 @default.
• W3107708185 cites W2105311106 @default.
• W3107708185 cites W2129525552 @default.
• W3107708185 cites W2129857191 @default.
• W3107708185 cites W2136170834 @default.
• W3107708185 cites W2137003853 @default.
• W3107708185 cites W2137262465 @default.
• W3107708185 cites W2171162078 @default.
• W3107708185 cites W2274197186 @default.
• W3107708185 cites W2440533561 @default.
• W3107708185 cites W2564634123 @default.
• W3107708185 cites W2767784465 @default.
• W3107708185 cites W2781604740 @default.
• W3107708185 cites W2800510715 @default.
• W3107708185 cites W2810481432 @default.
• W3107708185 cites W2911332901 @default.
• W3107708185 cites W2954909334 @default.
• W3107708185 cites W2960665032 @default.
• W3107708185 cites W2967592844 @default.
• W3107708185 doi "https://doi.org/10.1093/humrep/deaa303" @default.
• W3107708185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33600565" @default.
• W3107708185 hasPublicationYear "2020" @default.
• W3107708185 type Work @default.
• W3107708185 sameAs 3107708185 @default.
• W3107708185 citedByCount "33" @default.
• W3107708185 countsByYear W31077081852021 @default.
• W3107708185 countsByYear W31077081852022 @default.
• W3107708185 countsByYear W31077081852023 @default.
• W3107708185 crossrefType "journal-article" @default.
• W3107708185 hasAuthorship W3107708185A5009699749 @default.
• W3107708185 hasAuthorship W3107708185A5013538627 @default.
• W3107708185 hasAuthorship W3107708185A5021269128 @default.
• W3107708185 hasAuthorship W3107708185A5021977829 @default.
• W3107708185 hasAuthorship W3107708185A5037670442 @default.
• W3107708185 hasAuthorship W3107708185A5066635614 @default.
• W3107708185 hasBestOaLocation W31077081851 @default.
• W3107708185 hasConcept C105702510 @default.
• W3107708185 hasConcept C134018914 @default.
• W3107708185 hasConcept C16685009 @default.
• W3107708185 hasConcept C172680121 @default.
• W3107708185 hasConcept C2776953305 @default.
• W3107708185 hasConcept C2777495146 @default.
• W3107708185 hasConcept C2778164554 @default.
• W3107708185 hasConcept C2779066055 @default.
• W3107708185 hasConcept C2779234561 @default.
• W3107708185 hasConcept C2780197806 @default.
• W3107708185 hasConcept C2780771523 @default.
• W3107708185 hasConcept C2781207646 @default.
• W3107708185 hasConcept C46973012 @default.
• W3107708185 hasConcept C54355233 @default.
• W3107708185 hasConcept C71924100 @default.
• W3107708185 hasConcept C86803240 @default.
• W3107708185 hasConceptScore W3107708185C105702510 @default.
• W3107708185 hasConceptScore W3107708185C134018914 @default.
• W3107708185 hasConceptScore W3107708185C16685009 @default.
• W3107708185 hasConceptScore W3107708185C172680121 @default.
• W3107708185 hasConceptScore W3107708185C2776953305 @default.
• W3107708185 hasConceptScore W3107708185C2777495146 @default.
• W3107708185 hasConceptScore W3107708185C2778164554 @default.
• W3107708185 hasConceptScore W3107708185C2779066055 @default.
• W3107708185 hasConceptScore W3107708185C2779234561 @default.
• W3107708185 hasConceptScore W3107708185C2780197806 @default.
• W3107708185 hasConceptScore W3107708185C2780771523 @default.

• next