FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107714301> ?p ?o ?g. }

• W3107714301 endingPage "108114" @default.
• W3107714301 startingPage "108114" @default.
• W3107714301 abstract "Treatment with neurotrophins prevents degeneration of spiral ganglion cells (SGCs) after severe hair cell loss. In a previous study we demonstrated a long-lasting effect with brain-derived neurotrophic factor (BDNF) after cessation of treatment. In that study the survival of the SGC cell bodies was examined. Here we address the question whether their peripheral processes and central processes (axons) were protected by this treatment as well in the cochleas of the aforementioned study. Guinea pigs were deafened by co-administration of kanamycin and furosemide. Two weeks after deafening the right cochleas were implanted with an intracochlear electrode array combined with a cannula connected to an osmotic pump filled with BDNF solution. Four weeks later the treatment was stopped by surgically removing the osmotic pump. At that point, or another four or eight weeks later, the animals were sacrificed for histological analysis. Control groups consisted of normal-hearing animals, and three groups of deafened animals: two-weeks-deaf untreated animals, and six- and fourteen-weeks-deaf sham-treated animals. Cochleas were processed for analysis of: (1) the myelinated portion of peripheral processes in the osseous spiral lamina, (2) the cell bodies in Rosenthal's canal, and (3) axons in the internal acoustic meatus. Packing densities and cross-sectional areas were determined using light microscopy. Up to eight weeks after treatment cessation the numbers of peripheral processes and axons were significantly higher than in untreated cochleas of control animals. Whereas the numbers of cell bodies and axons were similar to those at the start of treatment, the peripheral processes were significantly less well preserved. This smaller protective effect was found mainly in the apical turns. Strategies to prevent SGC degeneration after hair cell loss should consider the differential effects on the various neural elements." @default.
• W3107714301 created "2020-12-07" @default.
• W3107714301 creator A5018005465 @default.
• W3107714301 creator A5021474600 @default.
• W3107714301 creator A5052453384 @default.
• W3107714301 creator A5064856966 @default.
• W3107714301 creator A5074556968 @default.
• W3107714301 date "2021-02-01" @default.
• W3107714301 modified "2023-10-13" @default.
• W3107714301 title "BDNF-mediated preservation of spiral ganglion cell peripheral processes and axons in comparison to that of their cell bodies" @default.
• W3107714301 cites W1487490912 @default.
• W3107714301 cites W1719470561 @default.
• W3107714301 cites W1859430127 @default.
• W3107714301 cites W1964000981 @default.
• W3107714301 cites W1964155978 @default.
• W3107714301 cites W1964248735 @default.
• W3107714301 cites W1967886362 @default.
• W3107714301 cites W1974113951 @default.
• W3107714301 cites W1985643560 @default.
• W3107714301 cites W1986131585 @default.
• W3107714301 cites W1987156959 @default.
• W3107714301 cites W1992695138 @default.
• W3107714301 cites W1995261715 @default.
• W3107714301 cites W2001047327 @default.
• W3107714301 cites W2005619612 @default.
• W3107714301 cites W2006904223 @default.
• W3107714301 cites W2008803709 @default.
• W3107714301 cites W2014222020 @default.
• W3107714301 cites W2019255057 @default.
• W3107714301 cites W2034040572 @default.
• W3107714301 cites W2034331964 @default.
• W3107714301 cites W2035266661 @default.
• W3107714301 cites W2036489897 @default.
• W3107714301 cites W2043784071 @default.
• W3107714301 cites W2046610720 @default.
• W3107714301 cites W2048710124 @default.
• W3107714301 cites W2049307047 @default.
• W3107714301 cites W2056732424 @default.
• W3107714301 cites W2058359348 @default.
• W3107714301 cites W2061063067 @default.
• W3107714301 cites W2063997093 @default.
• W3107714301 cites W2069855517 @default.
• W3107714301 cites W2070021689 @default.
• W3107714301 cites W2076669076 @default.
• W3107714301 cites W2088288879 @default.
• W3107714301 cites W2098537456 @default.
• W3107714301 cites W2115595764 @default.
• W3107714301 cites W2130323061 @default.
• W3107714301 cites W2142287756 @default.
• W3107714301 cites W2143374954 @default.
• W3107714301 cites W2152933007 @default.
• W3107714301 cites W2171161097 @default.
• W3107714301 cites W2326040854 @default.
• W3107714301 cites W2330501063 @default.
• W3107714301 cites W2345177852 @default.
• W3107714301 cites W2471308520 @default.
• W3107714301 cites W2474190992 @default.
• W3107714301 cites W2546135632 @default.
• W3107714301 cites W2569360263 @default.
• W3107714301 cites W2570803777 @default.
• W3107714301 cites W258122973 @default.
• W3107714301 cites W2744390003 @default.
• W3107714301 cites W2780425085 @default.
• W3107714301 cites W2794060085 @default.
• W3107714301 cites W2921270891 @default.
• W3107714301 cites W2949441841 @default.
• W3107714301 cites W2984014483 @default.
• W3107714301 cites W3008339469 @default.
• W3107714301 doi "https://doi.org/10.1016/j.heares.2020.108114" @default.
• W3107714301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33271438" @default.
• W3107714301 hasPublicationYear "2021" @default.
• W3107714301 type Work @default.
• W3107714301 sameAs 3107714301 @default.
• W3107714301 citedByCount "12" @default.
• W3107714301 countsByYear W31077143012021 @default.
• W3107714301 countsByYear W31077143012022 @default.
• W3107714301 countsByYear W31077143012023 @default.
• W3107714301 crossrefType "journal-article" @default.
• W3107714301 hasAuthorship W3107714301A5018005465 @default.
• W3107714301 hasAuthorship W3107714301A5021474600 @default.
• W3107714301 hasAuthorship W3107714301A5052453384 @default.
• W3107714301 hasAuthorship W3107714301A5064856966 @default.
• W3107714301 hasAuthorship W3107714301A5074556968 @default.
• W3107714301 hasBestOaLocation W31077143011 @default.
• W3107714301 hasConcept C105702510 @default.
• W3107714301 hasConcept C126322002 @default.
• W3107714301 hasConcept C141071460 @default.
• W3107714301 hasConcept C151626666 @default.
• W3107714301 hasConcept C160539049 @default.
• W3107714301 hasConcept C170493617 @default.
• W3107714301 hasConcept C185263204 @default.
• W3107714301 hasConcept C2778074680 @default.
• W3107714301 hasConcept C2778585322 @default.
• W3107714301 hasConcept C2779152698 @default.
• W3107714301 hasConcept C2780130748 @default.
• W3107714301 hasConcept C46762472 @default.
• W3107714301 hasConcept C71924100 @default.
• W3107714301 hasConceptScore W3107714301C105702510 @default.

• next