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- W3107714483 endingPage "173765" @default.
- W3107714483 startingPage "173765" @default.
- W3107714483 abstract "Abstract Peptidylarginine deiminase (PAD) family members have a vital role in maintaining the stability of the extracellular matrix (ECM) during remodelling in several heart diseases. PAD-mediated deamination, or citrullination, has been studied in different physiological and pathological conditions in the body. However, the role of PAD isoforms has not been fully studied in cardiovascular system. Citrullination is a post-translational modification that involves conversion of peptidyl-based arginine to peptidyl-based citrulline by PAD family members in a calcium-dependent manner. Upregulation of PADs have been observed in various cardiovascular diseases, including venous thrombosis, cardiac fibrosis, heart failure, atherosclerosis, coronary heart disease and acute inflammation. In this review, experimental aspects of in vivo and in vitro studies related to the roles PAD isoforms in cardiovascular diseases including mechanisms, pathophysiological and therapeutic properties are discussed. Pharmacological strategies for targeting PAD family proteins in cardiac diseases have not yet been studied. Furthermore, the role played by PAD family members in the remodelling process during the progression of cardiovascular diseases is not fully understood." @default.
- W3107714483 created "2020-12-07" @default.
- W3107714483 creator A5021824403 @default.
- W3107714483 creator A5045215649 @default.
- W3107714483 creator A5079299054 @default.
- W3107714483 creator A5086092215 @default.
- W3107714483 date "2021-01-01" @default.
- W3107714483 modified "2023-10-01" @default.
- W3107714483 title "Current knowledge into the role of the peptidylarginine deiminase (PAD) enzyme family in cardiovascular disease" @default.
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