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- W3107718211 abstract "Molecular monitoring of minimal residual disease (MRD) and BCR-ABL1 kinase domain (KD) mutation testing have a well consolidated role in the routine management of chronic myeloid leukemia (CML) patients, as they provide precious information for therapeutic decision-making. Molecular response levels are used to define whether a patient has an “optimal”, “warning”, or “failure” response to tyrosine kinase inhibitor (TKI) therapy. Mutation status may be useful to decide whether TKI therapy should be changed and which alternative TKI (or TKIs) are most likely to be effective. Real-time quantitative polymerase chain reaction (RQ-qPCR) and Sanger sequencing are currently the gold standard for molecular response monitoring and mutation testing, respectively. However, in recent years, novel technologies such as digital PCR (dPCR) and next-generation sequencing (NGS) have been evaluated. Here, we critically describe the main features of these old and novel technologies, provide an overview of the recently published studies assessing the potential clinical value of dPCR and NGS, and discuss how the state of the art might evolve in the next years." @default.
- W3107718211 created "2020-12-07" @default.
- W3107718211 creator A5016041461 @default.
- W3107718211 creator A5068166657 @default.
- W3107718211 creator A5071479311 @default.
- W3107718211 date "2020-11-27" @default.
- W3107718211 modified "2023-10-16" @default.
- W3107718211 title "Molecular Testing in CML between Old and New Methods: Are We at a Turning Point?" @default.
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- W3107718211 doi "https://doi.org/10.3390/jcm9123865" @default.
- W3107718211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7760306" @default.
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