FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107731347> ?p ?o ?g. }

• W3107731347 endingPage "2530" @default.
• W3107731347 startingPage "2530" @default.
• W3107731347 abstract "Natural cosmetic products have recently re-emerged as a novel tool able to counteract skin aging and skin related damages. In addition, recently achieved progress in nanomedicine opens a novel approach yielding from combination of modern nanotechnology with traditional treatment for innovative pharmacotherapeutics. In the present study, we investigated the antiaging effect of a pretreatment with Myrtus communis natural extract combined with a polycaprolactone nanofibrous scaffold (NanoPCL-M) on skin cell populations exposed to UV. We set up a novel model of skin on a bioreactor mimicking a crosstalk between keratinocytes, stem cells and fibroblasts, as in skin. Beta-galactosidase assay, indicating the amount of senescent cells, and viability assay, revealed that fibroblasts and stem cells pretreated with NanoPCL-M and then exposed to UV are superimposable to control cells, untreated and unexposed to UV damage. On the other hand, cells only exposed to UV stress, without NanoPCL-M pretreatment, exhibited a significantly higher yield of senescent elements. Keratinocyte-based 3D structures appeared disjointed after UV-stress, as compared to NanoPCL-M pretreated samples. Gene expression analysis performed on different senescence associated genes, revealed the activation of a molecular program of rejuvenation in stem cells pretreated with NanoPCL-M and then exposed to UV. Altogether, our results highlight a future translational application of NanoPCL-M to prevent skin aging." @default.
• W3107731347 created "2020-12-07" @default.
• W3107731347 creator A5000134199 @default.
• W3107731347 creator A5012256814 @default.
• W3107731347 creator A5012812911 @default.
• W3107731347 creator A5013390741 @default.
• W3107731347 creator A5018470862 @default.
• W3107731347 creator A5019290815 @default.
• W3107731347 creator A5038519376 @default.
• W3107731347 creator A5038805616 @default.
• W3107731347 creator A5042666924 @default.
• W3107731347 creator A5046171732 @default.
• W3107731347 creator A5050908666 @default.
• W3107731347 creator A5051416401 @default.
• W3107731347 creator A5053537497 @default.
• W3107731347 creator A5058064468 @default.
• W3107731347 creator A5060066281 @default.
• W3107731347 creator A5060449887 @default.
• W3107731347 creator A5069113353 @default.
• W3107731347 creator A5080742541 @default.
• W3107731347 date "2020-11-24" @default.
• W3107731347 modified "2023-09-24" @default.
• W3107731347 title "Smart Nanofibers with Natural Extracts Prevent Senescence Patterning in a Dynamic Cell Culture Model of Human Skin" @default.
• W3107731347 cites W1965600609 @default.
• W3107731347 cites W1974125906 @default.
• W3107731347 cites W1975766417 @default.
• W3107731347 cites W1996834901 @default.
• W3107731347 cites W1997692336 @default.
• W3107731347 cites W2012867962 @default.
• W3107731347 cites W2020596146 @default.
• W3107731347 cites W2023420172 @default.
• W3107731347 cites W2025423123 @default.
• W3107731347 cites W2034055159 @default.
• W3107731347 cites W2036435176 @default.
• W3107731347 cites W2046686235 @default.
• W3107731347 cites W2051830463 @default.
• W3107731347 cites W2058009653 @default.
• W3107731347 cites W2064864508 @default.
• W3107731347 cites W2066630518 @default.
• W3107731347 cites W2079206546 @default.
• W3107731347 cites W2097545575 @default.
• W3107731347 cites W2109062539 @default.
• W3107731347 cites W2123435369 @default.
• W3107731347 cites W2127160778 @default.
• W3107731347 cites W2128646449 @default.
• W3107731347 cites W2128978142 @default.
• W3107731347 cites W2144003426 @default.
• W3107731347 cites W2148105491 @default.
• W3107731347 cites W2157239215 @default.
• W3107731347 cites W2158713934 @default.
• W3107731347 cites W2165299044 @default.
• W3107731347 cites W2199236281 @default.
• W3107731347 cites W2229185417 @default.
• W3107731347 cites W2463086270 @default.
• W3107731347 cites W2588701511 @default.
• W3107731347 cites W2739062306 @default.
• W3107731347 cites W2770933853 @default.
• W3107731347 cites W2804599654 @default.
• W3107731347 cites W2912059386 @default.
• W3107731347 cites W2938521889 @default.
• W3107731347 cites W2940564657 @default.
• W3107731347 cites W2952948765 @default.
• W3107731347 cites W2970070477 @default.
• W3107731347 cites W3011646404 @default.
• W3107731347 cites W3011884952 @default.
• W3107731347 cites W4206233828 @default.
• W3107731347 doi "https://doi.org/10.3390/cells9122530" @default.
• W3107731347 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7760051" @default.
• W3107731347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33255167" @default.
• W3107731347 hasPublicationYear "2020" @default.
• W3107731347 type Work @default.
• W3107731347 sameAs 3107731347 @default.
• W3107731347 citedByCount "10" @default.
• W3107731347 countsByYear W31077313472021 @default.
• W3107731347 countsByYear W31077313472022 @default.
• W3107731347 countsByYear W31077313472023 @default.
• W3107731347 crossrefType "journal-article" @default.
• W3107731347 hasAuthorship W3107731347A5000134199 @default.
• W3107731347 hasAuthorship W3107731347A5012256814 @default.
• W3107731347 hasAuthorship W3107731347A5012812911 @default.
• W3107731347 hasAuthorship W3107731347A5013390741 @default.
• W3107731347 hasAuthorship W3107731347A5018470862 @default.
• W3107731347 hasAuthorship W3107731347A5019290815 @default.
• W3107731347 hasAuthorship W3107731347A5038519376 @default.
• W3107731347 hasAuthorship W3107731347A5038805616 @default.
• W3107731347 hasAuthorship W3107731347A5042666924 @default.
• W3107731347 hasAuthorship W3107731347A5046171732 @default.
• W3107731347 hasAuthorship W3107731347A5050908666 @default.
• W3107731347 hasAuthorship W3107731347A5051416401 @default.
• W3107731347 hasAuthorship W3107731347A5053537497 @default.
• W3107731347 hasAuthorship W3107731347A5058064468 @default.
• W3107731347 hasAuthorship W3107731347A5060066281 @default.
• W3107731347 hasAuthorship W3107731347A5060449887 @default.
• W3107731347 hasAuthorship W3107731347A5069113353 @default.
• W3107731347 hasAuthorship W3107731347A5080742541 @default.
• W3107731347 hasBestOaLocation W31077313471 @default.
• W3107731347 hasConcept C136229726 @default.
• W3107731347 hasConcept C1491633281 @default.

• next