FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107783684> ?p ?o ?g. }

• W3107783684 endingPage "105647" @default.
• W3107783684 startingPage "105647" @default.
• W3107783684 abstract "With the ambition of improving the management of pancreatic neuroendocrine tumors (P-NETs), we developed and preliminary validated a novel fluorine-18 labelled HSP90 ligand. A precursor containing methoxymethyl ethers protecting groups and a tosyl as leaving group was synthesized. The target compound was labeled with nucleophilic 18F-fluoride and the protecting groups was subsequently removed with hydrochloric acid before purification. In vitro cell- and frozen section autoradiography and in vivo animal studies were performed. The precursor was successfully synthesized and utilized in the 18F-radiolabeling giving 0.5-1.0 GBq of pure product with a synthesis time of 70 min. In vitro experiments indicated a high specific binding, but in vivo studies showed no tumor uptake due to fast hepatobiliary metabolism and excretion. Despite the unfavorable in vivo properties of the tracer, the promising results from in vitro autoradiography experiments in frozen sections of P-NETs from surgical resection encourage us to continue the project aiming the improvement of in vivo properties of the tracer." @default.
• W3107783684 created "2020-12-07" @default.
• W3107783684 creator A5000559526 @default.
• W3107783684 creator A5008347976 @default.
• W3107783684 creator A5011641736 @default.
• W3107783684 creator A5029953314 @default.
• W3107783684 creator A5038912293 @default.
• W3107783684 creator A5038993523 @default.
• W3107783684 creator A5041762599 @default.
• W3107783684 creator A5057419350 @default.
• W3107783684 creator A5057537239 @default.
• W3107783684 creator A5061049141 @default.
• W3107783684 creator A5068301533 @default.
• W3107783684 creator A5071324855 @default.
• W3107783684 creator A5076231651 @default.
• W3107783684 date "2021-02-01" @default.
• W3107783684 modified "2023-09-26" @default.
• W3107783684 title "18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand" @default.
• W3107783684 cites W1979592611 @default.
• W3107783684 cites W1999715990 @default.
• W3107783684 cites W2008074714 @default.
• W3107783684 cites W2017991681 @default.
• W3107783684 cites W2022234086 @default.
• W3107783684 cites W2055559275 @default.
• W3107783684 cites W2101594010 @default.
• W3107783684 cites W2118167053 @default.
• W3107783684 cites W2127975859 @default.
• W3107783684 cites W2133688312 @default.
• W3107783684 cites W2134498172 @default.
• W3107783684 cites W2166999544 @default.
• W3107783684 cites W2258569101 @default.
• W3107783684 cites W2382474752 @default.
• W3107783684 cites W2609016189 @default.
• W3107783684 cites W2770106257 @default.
• W3107783684 cites W2909039182 @default.
• W3107783684 doi "https://doi.org/10.1016/j.ejps.2020.105647" @default.
• W3107783684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33221456" @default.
• W3107783684 hasPublicationYear "2021" @default.
• W3107783684 type Work @default.
• W3107783684 sameAs 3107783684 @default.
• W3107783684 citedByCount "0" @default.
• W3107783684 crossrefType "journal-article" @default.
• W3107783684 hasAuthorship W3107783684A5000559526 @default.
• W3107783684 hasAuthorship W3107783684A5008347976 @default.
• W3107783684 hasAuthorship W3107783684A5011641736 @default.
• W3107783684 hasAuthorship W3107783684A5029953314 @default.
• W3107783684 hasAuthorship W3107783684A5038912293 @default.
• W3107783684 hasAuthorship W3107783684A5038993523 @default.
• W3107783684 hasAuthorship W3107783684A5041762599 @default.
• W3107783684 hasAuthorship W3107783684A5057419350 @default.
• W3107783684 hasAuthorship W3107783684A5057537239 @default.
• W3107783684 hasAuthorship W3107783684A5061049141 @default.
• W3107783684 hasAuthorship W3107783684A5068301533 @default.
• W3107783684 hasAuthorship W3107783684A5071324855 @default.
• W3107783684 hasAuthorship W3107783684A5076231651 @default.
• W3107783684 hasConcept C116569031 @default.
• W3107783684 hasConcept C150903083 @default.
• W3107783684 hasConcept C161790260 @default.
• W3107783684 hasConcept C170493617 @default.
• W3107783684 hasConcept C177322064 @default.
• W3107783684 hasConcept C178790620 @default.
• W3107783684 hasConcept C178907741 @default.
• W3107783684 hasConcept C185592680 @default.
• W3107783684 hasConcept C202751555 @default.
• W3107783684 hasConcept C207001950 @default.
• W3107783684 hasConcept C21951064 @default.
• W3107783684 hasConcept C2777436746 @default.
• W3107783684 hasConcept C2778718427 @default.
• W3107783684 hasConcept C55493867 @default.
• W3107783684 hasConcept C71240020 @default.
• W3107783684 hasConcept C86803240 @default.
• W3107783684 hasConceptScore W3107783684C116569031 @default.
• W3107783684 hasConceptScore W3107783684C150903083 @default.
• W3107783684 hasConceptScore W3107783684C161790260 @default.
• W3107783684 hasConceptScore W3107783684C170493617 @default.
• W3107783684 hasConceptScore W3107783684C177322064 @default.
• W3107783684 hasConceptScore W3107783684C178790620 @default.
• W3107783684 hasConceptScore W3107783684C178907741 @default.
• W3107783684 hasConceptScore W3107783684C185592680 @default.
• W3107783684 hasConceptScore W3107783684C202751555 @default.
• W3107783684 hasConceptScore W3107783684C207001950 @default.
• W3107783684 hasConceptScore W3107783684C21951064 @default.
• W3107783684 hasConceptScore W3107783684C2777436746 @default.
• W3107783684 hasConceptScore W3107783684C2778718427 @default.
• W3107783684 hasConceptScore W3107783684C55493867 @default.
• W3107783684 hasConceptScore W3107783684C71240020 @default.
• W3107783684 hasConceptScore W3107783684C86803240 @default.
• W3107783684 hasFunder F4320322327 @default.
• W3107783684 hasFunder F4320324119 @default.
• W3107783684 hasLocation W31077836841 @default.
• W3107783684 hasOpenAccess W3107783684 @default.
• W3107783684 hasPrimaryLocation W31077836841 @default.
• W3107783684 hasRelatedWork W1969799255 @default.
• W3107783684 hasRelatedWork W2012187280 @default.
• W3107783684 hasRelatedWork W2090776755 @default.
• W3107783684 hasRelatedWork W2397475176 @default.
• W3107783684 hasRelatedWork W2403924279 @default.
• W3107783684 hasRelatedWork W2950111249 @default.

• next