Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107788320> ?p ?o ?g. }
- W3107788320 endingPage "928" @default.
- W3107788320 startingPage "928" @default.
- W3107788320 abstract "Drugs that inhibit ion channel function by binding in the channel and preventing current flow, known as channel blockers, can be used as powerful tools for analysis of channel properties. Channel blockers are used to probe both the sophisticated structure and basic biophysical properties of ion channels. Gating, the mechanism that controls the opening and closing of ion channels, can be profoundly influenced by channel blocking drugs. Channel block and gating are reciprocally connected; gating controls access of channel blockers to their binding sites, and channel-blocking drugs can have profound and diverse effects on the rates of gating transitions and on the stability of channel open and closed states. This review synthesizes knowledge of the inherent intertwining of block and gating of excitatory ligand-gated ion channels, with a focus on the utility of channel blockers as analytic probes of ionotropic glutamate receptor channel function." @default.
- W3107788320 created "2020-12-07" @default.
- W3107788320 creator A5037516289 @default.
- W3107788320 creator A5053264855 @default.
- W3107788320 creator A5062919567 @default.
- W3107788320 date "2020-12-01" @default.
- W3107788320 modified "2023-09-27" @default.
- W3107788320 title "Interplay between Gating and Block of Ligand-Gated Ion Channels" @default.
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