Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107799182> ?p ?o ?g. }
- W3107799182 endingPage "105060" @default.
- W3107799182 startingPage "105060" @default.
- W3107799182 abstract "Chronic psychosocial stress during pregnancy and/or after birth, and the associated elevation in cortisol, is linked with the onset of behavioural disorders in childhood. Previously, prenatal stress has been shown to reduce neurosteroid pathways in the fetus and the levels of the neurosteroid and GABAA receptor agonist, allopregnanolone. In late gestation, elevated levels of GABAergic activity increases inhibitory tone and protects against excessive excitation. These levels of allopregnanolone may also contribute to promoting myelination, thus stress-induced suppression of protective neurosteroid levels may disrupt neurodevelopmental processes and can result in reduced myelination. The objective of this study was to examine whether prenatal and postnatal stress reduces levels of inhibitory pathways to result in behavioural, myelin, and GABAergic/glutamatergic pathway deficits in the hippocampus at a postnatal time point in the guinea pig equivalent to childhood in humans.Pregnant guinea pig dams were exposed to prenatal stress (PRE) with strobe light exposure for 2 h/day on gestational age (GA) 50, 55, 60 and 65 (term is ∼GA70), with postnatal stress (POST) caused by maternal separation for 2 h/day from postnatal day (PND) 1-7), or a double-hit of both stressors (PRE + POST). Control dams and offspring groups (CON) were handled at the same time each day without causing stress. Behavioural outcomes were assessed using open field and elevated plus maze testing on PND27. After euthanasia on PND30, plasma samples were collected for steroid quantification of cortisol, allopregnanolone and progesterone by ELISA. Hippocampal samples were collected to assess markers of oligodendrocyte development and mature cells by myelin basic protein (MBP) immunostaining and GABAergic and glutamatergic pathway component gene expression by real time PCR.Male guinea pig offspring exposed to prenatal stress exhibited hyperactive-like behaviour at childhood equivalence, while female offspring displayed anxious-like behaviour, to a lesser extent. In both sexes, MBP immunostaining was significantly decreased in the hippocampal region following prenatal stress, despite normal levels of MBP mRNA, which suggests a disruption to the MBP protein translation pathway. Many components of the GABAergic and glutamatergic pathways were disrupted following prenatal stress, notably GABAA receptor subunits, GABA production and uptake, glutamate ionotropic and metabotropic receptor subunits and glutamate transport. Following prenatal + postnatal stress, many of the behavioural and neurodevelopmental deficits were improved compared to the prenatal stress only group.We conclude that prenatal stress disrupts GABAergic and glutamatergic pathways that may contribute to reduced myelination and subsequent behavioural deficits in the offspring. The deficits seen following prenatal stress are ameliorated when paired with subsequent postnatal stress, which highlights the early postnatal period as an important treatment window." @default.
- W3107799182 created "2020-12-07" @default.
- W3107799182 creator A5008079998 @default.
- W3107799182 creator A5023093969 @default.
- W3107799182 creator A5038391174 @default.
- W3107799182 creator A5038552488 @default.
- W3107799182 creator A5069553709 @default.
- W3107799182 creator A5086964274 @default.
- W3107799182 date "2021-02-01" @default.
- W3107799182 modified "2023-10-15" @default.
- W3107799182 title "Effects of prenatal stress on behavioural and neurodevelopmental outcomes are altered by maternal separation in the neonatal period" @default.
- W3107799182 cites W1134685002 @default.
- W3107799182 cites W1503609844 @default.
- W3107799182 cites W1541257414 @default.
- W3107799182 cites W1559926259 @default.
- W3107799182 cites W1574239291 @default.
- W3107799182 cites W1634250897 @default.
- W3107799182 cites W1645012805 @default.
- W3107799182 cites W1966375501 @default.
- W3107799182 cites W1973115552 @default.
- W3107799182 cites W1982691004 @default.
- W3107799182 cites W1983585786 @default.
- W3107799182 cites W1985241009 @default.
- W3107799182 cites W1994532676 @default.
- W3107799182 cites W1995185151 @default.
- W3107799182 cites W1999602956 @default.
- W3107799182 cites W2000604051 @default.
- W3107799182 cites W2018440098 @default.
- W3107799182 cites W2023387505 @default.
- W3107799182 cites W2027299889 @default.
- W3107799182 cites W2031648971 @default.
- W3107799182 cites W2047177533 @default.
- W3107799182 cites W2049163404 @default.
- W3107799182 cites W2055109204 @default.
- W3107799182 cites W2067955179 @default.
- W3107799182 cites W2069783754 @default.
- W3107799182 cites W2070561085 @default.
- W3107799182 cites W2083794024 @default.
- W3107799182 cites W2088659194 @default.
- W3107799182 cites W2090558757 @default.
- W3107799182 cites W2109392677 @default.
- W3107799182 cites W2112851246 @default.
- W3107799182 cites W2134384514 @default.
- W3107799182 cites W2136251247 @default.
- W3107799182 cites W2143205261 @default.
- W3107799182 cites W2148586550 @default.
- W3107799182 cites W2163590618 @default.
- W3107799182 cites W2326136915 @default.
- W3107799182 cites W2339003246 @default.
- W3107799182 cites W2586609285 @default.
- W3107799182 cites W2587201088 @default.
- W3107799182 cites W2604153742 @default.
- W3107799182 cites W2726210277 @default.
- W3107799182 cites W2747200165 @default.
- W3107799182 cites W2766072535 @default.
- W3107799182 cites W2767646681 @default.
- W3107799182 cites W2811262331 @default.
- W3107799182 cites W2885071751 @default.
- W3107799182 cites W2886796995 @default.
- W3107799182 cites W2888968278 @default.
- W3107799182 cites W2984544781 @default.
- W3107799182 cites W3020033934 @default.
- W3107799182 doi "https://doi.org/10.1016/j.psyneuen.2020.105060" @default.
- W3107799182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33333379" @default.
- W3107799182 hasPublicationYear "2021" @default.
- W3107799182 type Work @default.
- W3107799182 sameAs 3107799182 @default.
- W3107799182 citedByCount "12" @default.
- W3107799182 countsByYear W31077991822021 @default.
- W3107799182 countsByYear W31077991822022 @default.
- W3107799182 countsByYear W31077991822023 @default.
- W3107799182 crossrefType "journal-article" @default.
- W3107799182 hasAuthorship W3107799182A5008079998 @default.
- W3107799182 hasAuthorship W3107799182A5023093969 @default.
- W3107799182 hasAuthorship W3107799182A5038391174 @default.
- W3107799182 hasAuthorship W3107799182A5038552488 @default.
- W3107799182 hasAuthorship W3107799182A5069553709 @default.
- W3107799182 hasAuthorship W3107799182A5086964274 @default.
- W3107799182 hasConcept C112672928 @default.
- W3107799182 hasConcept C123202247 @default.
- W3107799182 hasConcept C126322002 @default.
- W3107799182 hasConcept C134018914 @default.
- W3107799182 hasConcept C168258287 @default.
- W3107799182 hasConcept C170493617 @default.
- W3107799182 hasConcept C172680121 @default.
- W3107799182 hasConcept C2776443723 @default.
- W3107799182 hasConcept C2778338918 @default.
- W3107799182 hasConcept C2778654844 @default.
- W3107799182 hasConcept C2779234561 @default.
- W3107799182 hasConcept C2781161787 @default.
- W3107799182 hasConcept C44796713 @default.
- W3107799182 hasConcept C54355233 @default.
- W3107799182 hasConcept C71924100 @default.
- W3107799182 hasConcept C86803240 @default.
- W3107799182 hasConceptScore W3107799182C112672928 @default.
- W3107799182 hasConceptScore W3107799182C123202247 @default.
- W3107799182 hasConceptScore W3107799182C126322002 @default.
- W3107799182 hasConceptScore W3107799182C134018914 @default.