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- W3107800418 abstract "Glycosylation is performed by various glycosidases and glycosyltransferases. Glycan formation and degradation by these enzymes is crucial for various physiological events in cells. Recently, functional analysis of glycan-processing enzymes has actively been performed, and the enzymes are focused on novel drug targets. However, previously reported inhibitors for the glycan-processing enzymes have encountered major problems. Additionally, screening systems for the inhibitors of glycan-processing enzymes are lacking. Accordingly, we are developing cell-based fluorescence imaging systems for glycan-processing glycosidases and screening of their novel inhibitors. In this paper, we introduce the development of a quinone methide cleavage (QMC) fluorescent substrate platform for the glycan-processing glycosidase and the discovery of novel glycosidase inhibitors using these platform-based fluorescent substrates." @default.
- W3107800418 created "2020-12-07" @default.
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- W3107800418 date "2020-11-25" @default.
- W3107800418 modified "2023-09-27" @default.
- W3107800418 title "Development of Fluorescent Substrate for Glycan Processing Glycosidase, and Screening of the Novel Glycosidase Inhibitor" @default.
- W3107800418 doi "https://doi.org/10.4052/tigg.1977.4e" @default.
- W3107800418 hasPublicationYear "2020" @default.
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