Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107907635> ?p ?o ?g. }
- W3107907635 abstract "ABSTRACT Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biological functions in the cell and has been considered a drug target in relation to both neurodegenerative diseases and cancer. Therefore, access to well-characterized and robust tool compounds is essential for the continued investigation of the complex functions of this enzyme. Here, we report a collection of probes that are potent, selective, stable in serum, water-soluble, amenable to cell culture experiments, and inhibit both SIRT2 deacetylation and demyristoylation. Compared to the current landscape of SIRT2 inhibitors, this is a unique ensemble of features built into a single compound. We expect the developed chemotypes to find broad application in the interrogation of SIRT2 functions in both healthy and diseased cells, and to provide a foundation for the development of future therapeutics." @default.
- W3107907635 created "2020-12-07" @default.
- W3107907635 creator A5001768686 @default.
- W3107907635 creator A5015195115 @default.
- W3107907635 creator A5019847584 @default.
- W3107907635 creator A5040761742 @default.
- W3107907635 creator A5041984050 @default.
- W3107907635 creator A5046604348 @default.
- W3107907635 creator A5055954638 @default.
- W3107907635 creator A5059071312 @default.
- W3107907635 creator A5059646546 @default.
- W3107907635 creator A5081286281 @default.
- W3107907635 creator A5087822546 @default.
- W3107907635 date "2020-03-22" @default.
- W3107907635 modified "2023-09-26" @default.
- W3107907635 title "Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration" @default.
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