Matches in SemOpenAlex for { <https://semopenalex.org/work/W3107929142> ?p ?o ?g. }
- W3107929142 endingPage "156" @default.
- W3107929142 startingPage "139" @default.
- W3107929142 abstract "Neuroinflammation is the inflammatory responses that are involved in the pathogenesis of most neurological disorders. Glutaminase (GLS) is the enzyme that catalyzes the hydrolysis of glutamine to produce glutamate. Besides its well-known role in cellular metabolism and excitatory neurotransmission, GLS has recently been increasingly noticed to be up-regulated in activated microglia under pathological conditions. Furthermore, GLS overexpression induces microglial activation, extracellular vesicle secretion, and neuroinflammatory microenvironment formation, which, are compromised by GLS inhibitors in vitro and in vivo. These results indicate that GLS has more complicated implications in brain disease etiology than what are previously known. In this review, we introduce GLS isoforms, expression patterns in the body and the brain, and expression/activities regulation. Next, we discuss the metabolic and neurotransmission functions of GLS. Afterwards, we summarize recent findings of GLS-mediated microglial activation and pro-inflammatory extracellular vesicle secretion, which, in turns, induces neuroinflammation. Lastly, we provide a comprehensive discussion for the involvement of microglial GLS in the pathogenesis of various neurological disorders, indicating microglial GLS as a promising target to treat these diseases." @default.
- W3107929142 created "2020-12-07" @default.
- W3107929142 creator A5032421319 @default.
- W3107929142 creator A5035660182 @default.
- W3107929142 creator A5054389087 @default.
- W3107929142 creator A5062872782 @default.
- W3107929142 creator A5085191289 @default.
- W3107929142 creator A5088390160 @default.
- W3107929142 date "2021-02-01" @default.
- W3107929142 modified "2023-10-10" @default.
- W3107929142 title "Glutaminase in microglia: A novel regulator of neuroinflammation" @default.
- W3107929142 cites W1179759088 @default.
- W3107929142 cites W1535057417 @default.
- W3107929142 cites W1556988079 @default.
- W3107929142 cites W1599691548 @default.
- W3107929142 cites W1606818325 @default.
- W3107929142 cites W1696619846 @default.
- W3107929142 cites W1832520743 @default.
- W3107929142 cites W1840339480 @default.
- W3107929142 cites W1872488273 @default.
- W3107929142 cites W1880007786 @default.
- W3107929142 cites W1898138780 @default.
- W3107929142 cites W1907316344 @default.
- W3107929142 cites W1957302801 @default.
- W3107929142 cites W1963646537 @default.
- W3107929142 cites W1966279100 @default.
- W3107929142 cites W1968298120 @default.
- W3107929142 cites W1974399512 @default.
- W3107929142 cites W1978403015 @default.
- W3107929142 cites W1978885851 @default.
- W3107929142 cites W1979302263 @default.
- W3107929142 cites W1982737489 @default.
- W3107929142 cites W1985438873 @default.
- W3107929142 cites W1986973852 @default.
- W3107929142 cites W1989029018 @default.
- W3107929142 cites W1991288075 @default.
- W3107929142 cites W1992521533 @default.
- W3107929142 cites W1994344811 @default.
- W3107929142 cites W2000939252 @default.
- W3107929142 cites W2003661425 @default.
- W3107929142 cites W2005158904 @default.
- W3107929142 cites W2005931111 @default.
- W3107929142 cites W2013592080 @default.
- W3107929142 cites W2020931521 @default.
- W3107929142 cites W2024973092 @default.
- W3107929142 cites W2025478209 @default.
- W3107929142 cites W2027597645 @default.
- W3107929142 cites W2030912492 @default.
- W3107929142 cites W2034101077 @default.
- W3107929142 cites W2034369179 @default.
- W3107929142 cites W2034464297 @default.
- W3107929142 cites W2035036667 @default.
- W3107929142 cites W2035619630 @default.
- W3107929142 cites W2037919781 @default.
- W3107929142 cites W2038652783 @default.
- W3107929142 cites W2040900433 @default.
- W3107929142 cites W2042183116 @default.
- W3107929142 cites W2042997049 @default.
- W3107929142 cites W2046301872 @default.
- W3107929142 cites W2048366120 @default.
- W3107929142 cites W2049119986 @default.
- W3107929142 cites W2050880566 @default.
- W3107929142 cites W2051342581 @default.
- W3107929142 cites W2052227645 @default.
- W3107929142 cites W2052332287 @default.
- W3107929142 cites W2056174640 @default.
- W3107929142 cites W2056311398 @default.
- W3107929142 cites W2057512766 @default.
- W3107929142 cites W2058948754 @default.
- W3107929142 cites W2060050678 @default.
- W3107929142 cites W2062758194 @default.
- W3107929142 cites W2065113439 @default.
- W3107929142 cites W2065894198 @default.
- W3107929142 cites W2066234893 @default.
- W3107929142 cites W2066758197 @default.
- W3107929142 cites W2066800748 @default.
- W3107929142 cites W2068275410 @default.
- W3107929142 cites W2068826328 @default.
- W3107929142 cites W2071741008 @default.
- W3107929142 cites W2073607297 @default.
- W3107929142 cites W2073981494 @default.
- W3107929142 cites W2074064379 @default.
- W3107929142 cites W2074873270 @default.
- W3107929142 cites W2078257900 @default.
- W3107929142 cites W2079246504 @default.
- W3107929142 cites W2080880778 @default.
- W3107929142 cites W2081416052 @default.
- W3107929142 cites W2082363371 @default.
- W3107929142 cites W2082879602 @default.
- W3107929142 cites W2084259236 @default.
- W3107929142 cites W2087243986 @default.
- W3107929142 cites W2088526695 @default.
- W3107929142 cites W2089713288 @default.
- W3107929142 cites W2092719082 @default.
- W3107929142 cites W2094845811 @default.
- W3107929142 cites W2097605564 @default.
- W3107929142 cites W2100927341 @default.
- W3107929142 cites W2101060041 @default.