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- W3107965590 abstract "Sickle cell disease (SCD) is a monogenetic disorder caused by a mutation in the β-globin gene HBB leading to polymerization of red blood cells causing damage to cell membranes, increasing its rigidity and intravascular hemolysis. Multiple lines of evidence suggest that SCD can be viewed as pan-vasculopathy associated with multiple mechanisms but driven by hemoglobin S polymerization. Here we review the pathophysiology, clinical manifestations and management strategies for cerebrovascular disease, pulmonary hypertension and renal disease associated with SCD. These vascular phenotypes reflect the systemic nature of the complications of SCD and are a major threat to the well-being of patients with the disorder." @default.
- W3107965590 created "2020-12-07" @default.
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- W3107965590 date "2020-05-01" @default.
- W3107965590 modified "2023-09-26" @default.
- W3107965590 title "Vascular complications of sickle cell disease" @default.
- W3107965590 hasPublicationYear "2020" @default.
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