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- W3107978144 abstract "Bacteria in the genus Geobacter thrive in iron- and manganese-rich environments where the divalent cobalt cation (Co II ) accumulates to potentially toxic concentrations. Consistent with selective pressure from environmental exposure, the model laboratory representative Geobacter sulfurreducens grew with CoCl 2 concentrations (1 mM) typically used to enrich for metal-resistant bacteria from contaminated sites. We reconstructed from genomic data canonical pathways for Co II import and assimilation into cofactors (cobamides) that support the growth of numerous syntrophic partners. We also identified several metal efflux pumps, including one that was specifically upregulated by Co II . Cells acclimated to metal stress by downregulating non-essential proteins with metals and thiol groups that Co II preferentially targets. They also activated sensory and regulatory proteins involved in detoxification as well as pathways for protein and DNA repair. In addition, G. sulfurreducens upregulated respiratory chains that could have contributed to the reductive mineralization of the metal on the cell surface. Transcriptomic evidence also revealed pathways for cell envelope modification that increased metal resistance and promoted cell-cell aggregation and biofilm formation in stationary phase. These complex adaptive responses confer on Geobacter a competitive advantage for growth in metal-rich environments that are essential to the sustainability of cobamide-dependent microbiomes and the sequestration of the metal in hitherto unknown biomineralization reactions." @default.
- W3107978144 created "2020-12-07" @default.
- W3107978144 creator A5041920730 @default.
- W3107978144 creator A5051457536 @default.
- W3107978144 creator A5073009992 @default.
- W3107978144 creator A5089561883 @default.
- W3107978144 date "2020-11-26" @default.
- W3107978144 modified "2023-10-12" @default.
- W3107978144 title "Cobalt Resistance via Detoxification and Mineralization in the Iron-Reducing Bacterium Geobacter sulfurreducens" @default.
- W3107978144 cites W1521925072 @default.
- W3107978144 cites W1728555672 @default.
- W3107978144 cites W1828900086 @default.
- W3107978144 cites W1879772459 @default.
- W3107978144 cites W1964509770 @default.
- W3107978144 cites W1964694337 @default.
- W3107978144 cites W1965135816 @default.
- W3107978144 cites W1967362342 @default.
- W3107978144 cites W1969422680 @default.
- W3107978144 cites W1973387274 @default.
- W3107978144 cites W1978287170 @default.
- W3107978144 cites W1982934377 @default.
- W3107978144 cites W1983820606 @default.
- W3107978144 cites W1986582536 @default.
- W3107978144 cites W1988857358 @default.
- W3107978144 cites W1995840881 @default.
- W3107978144 cites W1998780145 @default.
- W3107978144 cites W2000835389 @default.
- W3107978144 cites W2002725220 @default.
- W3107978144 cites W2008720828 @default.
- W3107978144 cites W2012302404 @default.
- W3107978144 cites W2018148650 @default.
- W3107978144 cites W2019749092 @default.
- W3107978144 cites W2021911332 @default.
- W3107978144 cites W2025170774 @default.
- W3107978144 cites W2029055654 @default.
- W3107978144 cites W2029320828 @default.
- W3107978144 cites W2030645025 @default.
- W3107978144 cites W2035594105 @default.
- W3107978144 cites W2037551269 @default.
- W3107978144 cites W2040071863 @default.
- W3107978144 cites W2042752766 @default.
- W3107978144 cites W2048318735 @default.
- W3107978144 cites W2051048383 @default.
- W3107978144 cites W2060236322 @default.
- W3107978144 cites W2061670564 @default.
- W3107978144 cites W2062114257 @default.
- W3107978144 cites W2065653048 @default.
- W3107978144 cites W2069666755 @default.
- W3107978144 cites W2073087806 @default.
- W3107978144 cites W2075029013 @default.
- W3107978144 cites W2076561283 @default.
- W3107978144 cites W2079205419 @default.
- W3107978144 cites W2084168858 @default.
- W3107978144 cites W2093172249 @default.
- W3107978144 cites W2094084646 @default.
- W3107978144 cites W2098487647 @default.
- W3107978144 cites W2104785052 @default.
- W3107978144 cites W2104808495 @default.
- W3107978144 cites W2107247090 @default.
- W3107978144 cites W21086990 @default.
- W3107978144 cites W2111569769 @default.
- W3107978144 cites W2111683196 @default.
- W3107978144 cites W2112382496 @default.
- W3107978144 cites W2112791784 @default.
- W3107978144 cites W2119374551 @default.
- W3107978144 cites W2120061656 @default.
- W3107978144 cites W2120391576 @default.
- W3107978144 cites W2123273294 @default.
- W3107978144 cites W2124765964 @default.
- W3107978144 cites W2125021980 @default.
- W3107978144 cites W2132285032 @default.
- W3107978144 cites W2133477833 @default.
- W3107978144 cites W2135435872 @default.
- W3107978144 cites W2138779519 @default.
- W3107978144 cites W2140201534 @default.
- W3107978144 cites W2140665078 @default.
- W3107978144 cites W2145404025 @default.
- W3107978144 cites W2152308524 @default.
- W3107978144 cites W2156333289 @default.
- W3107978144 cites W2160662164 @default.
- W3107978144 cites W2162792752 @default.
- W3107978144 cites W2163640492 @default.
- W3107978144 cites W2166578833 @default.
- W3107978144 cites W2172196261 @default.
- W3107978144 cites W2193878940 @default.
- W3107978144 cites W2271065496 @default.
- W3107978144 cites W2289298963 @default.
- W3107978144 cites W2304692062 @default.
- W3107978144 cites W2341520504 @default.
- W3107978144 cites W2410607597 @default.
- W3107978144 cites W2419061112 @default.
- W3107978144 cites W2497004153 @default.
- W3107978144 cites W2518467579 @default.
- W3107978144 cites W2531264461 @default.
- W3107978144 cites W2582708549 @default.
- W3107978144 cites W2597506409 @default.
- W3107978144 cites W2606757801 @default.
- W3107978144 cites W2749464300 @default.
- W3107978144 cites W2780450926 @default.
- W3107978144 cites W2806424299 @default.