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- W3108047084 abstract "In previous studies, stage III patients with melanomas expressing PD-L1 in more than 5% of their cells had improved recurrence-free survival with anti-PD1 adjuvant therapy. In this context, we examined PD-L1 expression in primary cutaneous melanomas in the vertical growth phase to identify a possible biomarker. This was a retrospective study including 66 patients with invasive primary cutaneous melanomas. We assessed patient clinical and histopathologic data and performed immunohistochemical assays with melanoma specimens from the patients to evaluate PD-L1, PD-1, CD3, CD8 and FoxP3 expression. We observed PD-L1 expression in 21% (14/66) of our samples, and this expression correlated with increased melanoma thickness (P = .002) and nodular-type melanoma (P = .001). After adjusting for tumor thickness using a logistic regression test, the association of PD-L1 with nodular-type melanoma persisted. Nodular-type melanoma was 6.48 times more likely to be positive for PD-L1 than other histologic types (P = .014; 95% CI 1.46-28.82). As expected, PD-L1 expression correlated with the number of PD-1-expressing cells in the tumor-infiltrating lymphocyte population (P = .04). No correlation with PD-L1 was observed for age, sex, primary site, skin phototype, ulceration status, sentinel lymph node status, metastasis development or survival. Regarding the immune profile of the tumor-infiltrating lymphocytes, no significant differences were observed in the numbers of CD3+, CD8+FoxP3−, CD8−FoxP3+ and CD8+FoxP3+ cells by immunohistochemistry. Nodular-type melanoma is associated with PD-L1 expression and may be a suitable candidate for adjuvant therapy of primary melanomas in future studies." @default.
- W3108047084 created "2020-12-07" @default.
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- W3108047084 date "2020-12-01" @default.
- W3108047084 modified "2023-09-27" @default.
- W3108047084 title "18509 Nodular primary cutaneous melanoma is associated with PD-L1 expression" @default.
- W3108047084 doi "https://doi.org/10.1016/j.jaad.2020.06.492" @default.
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