FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3108070214> ?p ?o ?g. }

• W3108070214 abstract "Abstract Background Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood. Methods A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12–16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models. Results In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: − 0.01, 0.09), 0.02 (95%CrI: − 0.03, 0.07), and 0.03 (95%CrI: − 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), − 0.17 (95% CrI: − 0.28, − 0.07), and 0.12 (95% CrI: − 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a − 1.69 (95% CrI: − 2.98, − 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls. Conclusion Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects—differing in magnitude and direction—on fetal thyroid hormones." @default.
• W3108070214 created "2020-12-07" @default.
• W3108070214 creator A5013871779 @default.
• W3108070214 creator A5023510912 @default.
• W3108070214 creator A5037487659 @default.
• W3108070214 creator A5041564633 @default.
• W3108070214 creator A5047077004 @default.
• W3108070214 creator A5047932271 @default.
• W3108070214 creator A5052650664 @default.
• W3108070214 creator A5074520078 @default.
• W3108070214 creator A5079321464 @default.
• W3108070214 date "2020-11-26" @default.
• W3108070214 modified "2023-10-08" @default.
• W3108070214 title "Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort" @default.
• W3108070214 cites W1007495478 @default.
• W3108070214 cites W1268969431 @default.
• W3108070214 cites W1972238619 @default.
• W3108070214 cites W1975902105 @default.
• W3108070214 cites W1980335896 @default.
• W3108070214 cites W1993650845 @default.
• W3108070214 cites W2001246172 @default.
• W3108070214 cites W2007712704 @default.
• W3108070214 cites W2031375082 @default.
• W3108070214 cites W2039774973 @default.
• W3108070214 cites W2056547176 @default.
• W3108070214 cites W2067215286 @default.
• W3108070214 cites W2071534142 @default.
• W3108070214 cites W2077104587 @default.
• W3108070214 cites W2087275243 @default.
• W3108070214 cites W2092198782 @default.
• W3108070214 cites W2098379965 @default.
• W3108070214 cites W2100493261 @default.
• W3108070214 cites W2110541778 @default.
• W3108070214 cites W2155805677 @default.
• W3108070214 cites W2157024108 @default.
• W3108070214 cites W2171691690 @default.
• W3108070214 cites W2172114836 @default.
• W3108070214 cites W2321635716 @default.
• W3108070214 cites W2399401067 @default.
• W3108070214 cites W2412905839 @default.
• W3108070214 cites W2462369290 @default.
• W3108070214 cites W2533702448 @default.
• W3108070214 cites W2564881721 @default.
• W3108070214 cites W2565954130 @default.
• W3108070214 cites W2771096888 @default.
• W3108070214 cites W2792192142 @default.
• W3108070214 cites W2809882610 @default.
• W3108070214 cites W2888209655 @default.
• W3108070214 cites W2895792025 @default.
• W3108070214 cites W2951650251 @default.
• W3108070214 cites W2954868045 @default.
• W3108070214 cites W2963574220 @default.
• W3108070214 cites W2972833271 @default.
• W3108070214 cites W3000479659 @default.
• W3108070214 cites W3010698963 @default.
• W3108070214 cites W3011002735 @default.
• W3108070214 cites W3016540095 @default.
• W3108070214 doi "https://doi.org/10.1186/s12940-020-00679-7" @default.
• W3108070214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7690128" @default.
• W3108070214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33243245" @default.
• W3108070214 hasPublicationYear "2020" @default.
• W3108070214 type Work @default.
• W3108070214 sameAs 3108070214 @default.
• W3108070214 citedByCount "19" @default.
• W3108070214 countsByYear W31080702142021 @default.
• W3108070214 countsByYear W31080702142022 @default.
• W3108070214 countsByYear W31080702142023 @default.
• W3108070214 crossrefType "journal-article" @default.
• W3108070214 hasAuthorship W3108070214A5013871779 @default.
• W3108070214 hasAuthorship W3108070214A5023510912 @default.
• W3108070214 hasAuthorship W3108070214A5037487659 @default.
• W3108070214 hasAuthorship W3108070214A5041564633 @default.
• W3108070214 hasAuthorship W3108070214A5047077004 @default.
• W3108070214 hasAuthorship W3108070214A5047932271 @default.
• W3108070214 hasAuthorship W3108070214A5052650664 @default.
• W3108070214 hasAuthorship W3108070214A5074520078 @default.
• W3108070214 hasAuthorship W3108070214A5079321464 @default.
• W3108070214 hasBestOaLocation W31080702141 @default.
• W3108070214 hasConcept C105795698 @default.
• W3108070214 hasConcept C122048520 @default.
• W3108070214 hasConcept C126322002 @default.
• W3108070214 hasConcept C134018914 @default.
• W3108070214 hasConcept C2777886399 @default.
• W3108070214 hasConcept C2778288131 @default.
• W3108070214 hasConcept C2779234561 @default.
• W3108070214 hasConcept C2780914630 @default.
• W3108070214 hasConcept C3018923374 @default.
• W3108070214 hasConcept C33923547 @default.
• W3108070214 hasConcept C42407357 @default.
• W3108070214 hasConcept C46973012 @default.
• W3108070214 hasConcept C526584372 @default.
• W3108070214 hasConcept C54355233 @default.
• W3108070214 hasConcept C71315377 @default.
• W3108070214 hasConcept C71924100 @default.
• W3108070214 hasConcept C72563966 @default.
• W3108070214 hasConcept C86803240 @default.
• W3108070214 hasConceptScore W3108070214C105795698 @default.
• W3108070214 hasConceptScore W3108070214C122048520 @default.
• W3108070214 hasConceptScore W3108070214C126322002 @default.
• W3108070214 hasConceptScore W3108070214C134018914 @default.

• next