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- W3108082765 abstract "Abstract Background Salmonella enterica serovar Enteritidis (SE) is one of the pathogenic bacteria, which affects poultry production and poses a severe threat to public health. Chicken meat and eggs are the main sources of human salmonellosis. DNA methylation is involved in regulatory processes including gene expression, chromatin structure and genomic imprinting. To understand the methylation regulation in the response to SE inoculation in chicken, the genome-wide DNA methylation profile following SE inoculation was analyzed through whole-genome bisulfite sequencing in the current study. Results There were 185,362,463 clean reads and 126,098,724 unique reads in the control group, and 180,530,750 clean reads and 126,782,896 unique reads in the inoculated group. The methylation density in the gene body was higher than that in the upstream and downstream regions of the gene. There were 8946 differentially methylated genes (3639 hypo-methylated genes, 5307 hyper-methylated genes) obtained between inoculated and control groups. Methylated genes were mainly enriched in immune-related Gene Ontology (GO) terms and metabolic process terms. Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, FoxO signaling pathway, Wnt signaling pathway and several metabolism-related pathways were significantly enriched. The density of differentially methylated cytosines in miRNAs was the highest. HOX genes were widely methylated. Conclusions The genome-wide DNA methylation profile in the response to SE inoculation in chicken was analyzed. SE inoculation promoted the DNA methylation in the chicken cecum and caused methylation alteration in immune- and metabolic- related genes. Wnt signal pathway, miRNAs and HOX gene family may play crucial roles in the methylation regulation of SE inoculation in chicken. The findings herein will deepen the understanding of epigenetic regulation in the response to SE inoculation in chicken." @default.
- W3108082765 created "2020-12-07" @default.
- W3108082765 creator A5008811987 @default.
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- W3108082765 date "2020-11-23" @default.
- W3108082765 modified "2023-10-10" @default.
- W3108082765 title "Chicken cecal DNA methylome alteration in the response to Salmonella enterica serovar Enteritidis inoculation" @default.
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- W3108082765 doi "https://doi.org/10.1186/s12864-020-07174-w" @default.
- W3108082765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7681971" @default.
- W3108082765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33225883" @default.
- W3108082765 hasPublicationYear "2020" @default.
- W3108082765 type Work @default.